Results 71 to 80 of about 2,639 (160)

Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

Molecular Metabolism, 2015
Objective: Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the ...
Samantha E. Adamson, Akshaya K. Meher, Yu-hsin Chiu, Joanna K. Sandilos, Nathaniel P. Oberholtzer, Natalie N. Walker, Stefan R. Hargett, Scott A. Seaman, Shayn M. Peirce-Cottler, Brant E. Isakson, Coleen A. McNamara, Susanna R. Keller, Thurl E. Harris, Douglas A. Bayliss, Norbert Leitinger   +14 more
doaj   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, Volume 603, Issue 15, Page 4367-4381, 1 August 2025.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, Volume 603, Issue 15, Page 4237-4253, 1 August 2025.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

The Journal of Physiology, Volume 603, Issue 15, Page 4409-4432, 1 August 2025.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell, Danielle Johnston, Ayushi Bhatt, Zahra Kardan, Dan Stefan, Andrew Bysice, Samar Sayedyahossein, Lina Dagnino, Matthew Cecchini, Sampath Kumar Loganathan, Kathryn Roth, Silvia Penuela   +11 more
wiley   +1 more source

Regulation of Pannexin 1 Surface Expression by Extracellular ATP: Potential Implications for Nervous System Function in Health and Disease

Frontiers in Cellular Neuroscience, 2017
Pannexin 1 (Panx1) channels are widely recognized for their role in ATP release, and as follows, their function is closely tied to that of ATP-activated P2X7 purinergic receptors (P2X7Rs).
Leigh A. Swayne, Leigh A. Swayne, Andrew K. J. Boyce   +2 more
doaj   +1 more source

Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
The gut microbiota regulates the gut–brain–immune axis, modulating neuroimmune interactions in inflammatory bowel disease (IBD). Microbiota‐derived metabolites influence immune cells, driving cytokine release that activates dorsal root ganglion (DRG) neurons.
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability

Frontiers in Cellular Neuroscience, 2018
Neurite formation relies on finely-tuned control of the cytoskeleton. Here we identified a novel protein-protein interaction between the ion and metabolite channel protein Pannexin 1 (Panx1) and collapsin response mediator protein 2 (Crmp2), a positive ...
Xiaoxue Xu, Leigh E. Wicki-Stordeur, Juan C. Sanchez-Arias, Mei Liu, Mei Liu, Maria S. Weaver, Catherine S. W. Choi, Leigh A. Swayne, Leigh A. Swayne, Leigh A. Swayne   +9 more
doaj   +1 more source

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +1 more source

Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice

Biomolecules
Pannexin1 (Panx1) ATP channels are important in adipocyte biology, potentially influencing energy storage and expenditure. We compared the metabolic phenotype of young (14 weeks old) and mature (20 weeks old) wild-type (WT) and Panx1−/− mice exposed or not to cold (6 °C) during 28 days, a condition promoting adipocyte browning.
Molica, Filippo, Ehrlich, Avigail, Pelli, Graziano, Rusiecka, Olga, Montessuit, Christophe Albert, Chanson, Marc, Kwak, Brenda   +6 more
openaire   +4 more sources

A comparative antibody analysis of Pannexin1 expression in four rat brain regions reveals varying subcellular localizations

Frontiers in Pharmacology, 2013
Pannexin1 (Panx1) channels release cytosolic ATP in response to signaling pathways. Panx1 is highly expressed in the central nervous system. We used four antibodies with different Panx1 anti-peptide epitopes to analyze four regions of rat brain.
Angela C Cone, Cinzia eAmbrosi, Eliana eScemes, Maryann E Martone, Maryann E Martone, Gina eSosinsky, Gina eSosinsky   +6 more
doaj   +1 more source