Results 81 to 90 of about 2,639 (160)

The C-terminal activating domain promotes Panx1 channel opening

ABSTRACTPannexin 1 (Panx1) constitutes a large pore channel responsible for the release of ATP from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore.
Erik Henze, Jacqueline J. Ehrlich, Janice L. Robertson, Toshimitsu Kawate   +3 more
openaire   +2 more sources

Targeting pannexin1 improves seizure outcome.

PLoS ONE, 2011
Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been implicated in epilepsy.
Marcelo F Santiago, Jana Veliskova, Naman K Patel, Sarah E Lutz, Dorothee Caille, Anne Charollais, Paolo Meda, Eliana Scemes   +7 more
doaj   +1 more source

Biochemical and Functional Analyses of PANX1 Variants [PDF]

, 2019
Pannexin 1 (PANX1) is a glycoprotein capable of forming large-pore single-membrane channels permeable to signaling molecules such as ATP. In this study, we interrogated different domains by introducing naturally occurring variants reported in melanoma and assessed their impact on the channel function of PANX1 at the cell surface.
openaire  

Emerging functions of Pannexin 1 in the eye

Frontiers in Cellular Neuroscience, 2014
Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach, Stefan eKurtenbach, Georg eZoidl   +2 more
doaj   +1 more source

Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice

Frontiers in Cellular Neuroscience, 2014
The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca2+ concentration and NMDA receptor (NMDAR ...
Alvaro O. Ardiles, Carolina eFlores-Muñoz, Gabriela eToro-Ayala, Ana María Cárdenas, Adrian G Palacios, Pablo eMuñoz, Pablo eMuñoz, Marco eFuenzalida, Juan C Saez, Juan C Saez, Agustin D Martinez   +10 more
doaj   +1 more source

Panx1 Promotes Cisplatin-induced Apoptosis of A549 Cells by Regulating ATP/IP3 Pathway

Zhongliu Fangzhi Yanjiu, 2021
Objective To observe the regulation of Panx1 on ATP/IP3 signaling pathway and its mechanism during cisplatin-induced apoptosis of lung adenocarcinoma cells. Methods Human lung adenocarcinoma cell line A549 was used as the research object and carbenoxolone (CBX) was used as a drug interference tool. A549 cells were divided into normal control group, the
LONG Wenqing, ZHANG Huili, XIE Haijuan, WANG Yuxing, ZHANG Lijun, YU Hongnyu, WANG Lin   +6 more
openaire   +1 more source

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Cell Death & Disease
AbstractDiscovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious diseases.
Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon   +23 more
openaire   +5 more sources

Global pannexin 1 deletion increases tumor‐infiltrating lymphocytes in the BRAF/Pten mouse melanoma model

Molecular Oncology
Immunotherapies for malignant melanoma seek to boost the anti‐tumoral response of CD8+ T cells, but have a limited patient response rate, in part due to limited tumoral immune cell infiltration.
Rafael E. Sanchez‐Pupo, Garth A. Finch, Danielle E. Johnston, Heather Craig, Rober Abdo, Kevin Barr, Steven Kerfoot, Lina Dagnino, Silvia Penuela   +8 more
doaj   +1 more source

The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector and memory responses

iScience
Summary: Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in vivo,
Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S. Beniwal, Chloe L. Leff, Changwei Peng, Nhan L. Tran, Stephen C. Jameson, Henrique Borges da Silva   +14 more
doaj   +1 more source

Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

eLife
Protein phosphorylation is one of the major molecular mechanisms regulating protein activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel permeable to ATP and other cellular metabolites.
Zheng Ruan, Junuk Lee, Yangyang Li, Juan Du, Wei Lü   +4 more
doaj   +1 more source