Results 1 to 10 of about 206,427 (382)

Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats

Scientific Reports, 2021
Paracetamol is extensively consumed as an analgesic and antipyretic drug, but at a high dose level, it leads to deleterious side effects, such as hepatic and nephrotoxicity.
Amera Abd El Latif, Doaa H. Assar, Ebtihal M. Elkaw, Hanafy A. Hamza, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Ragaa A. Hamouda   +6 more
doaj   +2 more sources

An Updated Review on the Metabolite (AM404)-Mediated Central Mechanism of Action of Paracetamol (Acetaminophen): Experimental Evidence and Potential Clinical Impact

Journal of Pain Research, 2023
Christophe Mallet,1 Jules Desmeules,2 Rassa Pegahi,3 Alain Eschalier1 1Université Clermont Auvergne, INSERM, NEURO-DOL Basics & Clinical Pharmacology of Pain, Clermont-Ferrand, France; 2Faculty of Medicine and The School of Pharmaceutical Sciences ...
Mallet C, Desmeules J, Pegahi R, Eschalier A   +3 more
doaj   +2 more sources

Prehospital analgesia for trauma-related pain by paramedics: a comparative retrospective observational study of paracetamol, nalbuphine plus paracetamol, and piritramide [PDF]

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background In this retrospective observational study, we compared the efficacy and safety of paracetamol compared with those of nalbuphine plus paracetamol and piritramide in prehospital analgesia for trauma-related pain administered by paramedics ...
Jonas Lohmann, Martin Deicke, Marvin Deslandes, Julia Johanna Grannemann, Lydia Johnson Kolaparambil Varghese, Jochen Hinkelbein, Annika Hoyer, Matthias Kalmbach, Thomas Plappert, Bernd Strickmann, Mathini Vaseekaran, Tobias Vollmer, Gerrit Jansen   +12 more
doaj   +2 more sources

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants.

Cochrane Database of Systematic Reviews, 2022
BACKGROUND In preterm newborns, the ductus arteriosus frequently fails to close and the infants require medical or surgical closure of the patent ductus arteriosus (PDA).
A. Ohlsson, P. Shah
semanticscholar   +1 more source

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease

Expert Opinion on Drug Metabolism & Toxicology, 2023
Introduction Paracetamol is one of the most used medicines worldwide and is the most common important poisoning in high-income countries. In overdose, paracetamol causes dose-dependent hepatotoxicity.
Annabelle S Chidiac, N. Buckley, Firouzeh Noghrehchi, R. Cairns   +3 more
semanticscholar   +1 more source

Keracunan Parasetamol Pada Kucing Dan Anjing: Gejala Klinis dan Terapi

Jurnal Ilmu Peternakan dan Veteriner Tropis, 2020
Acetaminophen, commonly known as paracetamol, is a non-steroidal anti-inflammatory drug commonly used in human medicine for its antipyretic and analgesic action.
Yanuartono Yanuartono, Alfarisa Nururrozi, Soedarmanto Indarjulianto, Slamet Raharjo, Hary Purnamaningsih, Nurman Haribowo   +5 more
doaj   +3 more sources

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials

British Journal of Sports Medicine, 2023
Objective Clinical guidelines recommend exercise as a core treatment for knee or hip osteoarthritis (OA). However, how its analgesic effect compares to analgesics, for example, oral non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol—the most ...
Q. Weng, S. Goh, Jing Wu, M. Persson, Jie Wei, A. Sarmanova, Xiao-xiao Li, M. Hall, M. Doherty, T. Jiang, C. Zeng, Guanghua Lei, Weiya Zhang   +12 more
semanticscholar   +1 more source

Prunus laurocerasus L. Extracts Prevent Paracetamolinduced Nephrotoxicity by Regulating Antioxidant Status: An Experimental Animal Model

Hittite Journal of Science and Engineering, 2022
Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties.
Kaan Kaltalıoğlu
doaj   +1 more source

Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism

Future Journal of Pharmaceutical Sciences, 2023
Background Drug metabolism is crucial to attaining the therapeutic index of any drug. The metabolism and elimination of the drugs are governed mainly by P-glycoprotein (P-gp) and Cytochrome P450 (CYP).
Ravindra Babu Pingili, Sridhar Vemulapalli, Manideep V. V. N. Gadamsetty, Divya Presingu, Ruthvik Katuri, Vijayalakshmi Rachamsetty, Naveen Babu Kilaru   +6 more
doaj   +1 more source

Paracetamol: A Review of Guideline Recommendations

Journal of Clinical Medicine, 2021
Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and pain-related disability, which are expected to rise with the rapid global population aging. Current medical treatments provide only partial relief. Furthermore, non-
U. Freo, C. Ruocco, A. Valerio, I. Scagnol, E. Nisoli   +4 more
semanticscholar   +1 more source