Results 11 to 20 of about 8,981 (169)
Paraoxonase 1 Phenotype and Paraoxonase Activity in Asthmatic Patients
Iranian Journal of Allergy, Asthma and Immunology, 2015 Oxidative stress is involved in the pathogenesis of asthma. Paraoxonase 1 (PON1) and arylesterase are esterase enzymes displaying antioxidant characteristics.
Nurhan Sarioglu +4 more
doaj +4 more sources
Misconceptions about paraoxonase-1
Brazilian Journal of Otorhinolaryngology, 2022 Michael Mackness, Eser Y. Sozmen
doaj +4 more sources
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids [PDF]
Journal of Lipid Research, 2004 To determine the causes responsible for a preferential decrease of paraoxonase activity, which has been observed in the serum of patients with cardiovascular diseases, the inactivation or inhibition of paraoxonase 1 (PON1) by various endogenous factors ...
Su Duy Nguyen, Dai-Eun Sok
doaj +3 more sources
Dietary cholesterol increases paraoxonase 1 enzyme activity [PDF]
Journal of Lipid Research, 2012 HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk ...
Daniel S. Kim +10 more
doaj +3 more sources
Paraoxonase 1 Activity and Survival in Sepsis Patients
Balkan Medical Journal, 2015 Background: Sepsis is a state of augmented oxidative stress and diminished antioxidant capacity. High density lipoprotein (HDL) particles were shown to possess antioxidant and anti-inflammatory properties, as well as Paraoxonase 1 (PON1), which is an ...
Volkan İnal +4 more
doaj +7 more sources
Paraoxonase 1 polymorphisms and survival [PDF]
European Journal of Human Genetics, 2004 The antioxidant enzyme paraoxonase 1 (PON1) has previously been suggested to confer protection against coronary heart disease (CHD), one of the main causes of death in the Western world. Two coding polymorphisms, 55M/L and 192Q/R, and a promoter variant, -107C/T, has been extensively studied with respect to susceptibility to CHD. In this study, we have
Christiansen, Lene +3 more
openaire +3 more sources
Paraoxonase 1 in neurological disorders [PDF]
Redox Report, 2013 Paroxonase 1 displays multiple physiological activities that position it as a putative player in the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the role of paraoxonase 1 (PON1) as a factor in the risk of stroke and the major neurodegenerative diseases.
Teresita, Menini, Alejandro, Gugliucci
openaire +2 more sources
Haplotype-Phenotype Relationships of Paraoxonase-1 [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2005 Abstract Paraoxonase 1 (PON1) is an enzyme with multiple activities, including detoxification of organophosphates. It is believed to be important in preventing neurotoxic damage and has also been implicated in atherosclerosis. The PON1 gene contains five common polymorphisms, three in the promoter (−909G > C, −162A > G ...
Jia, Chen +4 more
openaire +2 more sources
Solubilization and Humanization of Paraoxonase-1 [PDF]
Journal of Lipids, 2012 Paraoxonase-1 (PON1) is a serum protein, the activity of which is related to susceptibility to cardiovascular disease and intoxication by organophosphorus (OP) compounds. It may also be involved in innate immunity, and it is a possible lead molecule in the development of a catalytic bioscavenger of OP pesticides and nerve agents.
Mohosin Sarkar +8 more
openaire +2 more sources
The Role of PON1 Variants in Disease Susceptibility in a Turkish Population
Global Medical Genetics, 2020 Paraoxonase 1 (PON1) enzyme plays a major role in antioxidant defense and protects the cells against reactive species. The most common PON1 Q192R and L55M polymorphisms are responsible for a wide variation of PON1 activity, which showed an up to 13-fold ...
Mahmoud Abudayyak +4 more
doaj +1 more source