Results 31 to 40 of about 8,981 (169)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents

Romanian Journal of Laboratory Medicine, 2015
Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for ...
Sandor Raluca, Leucuta Daniel, Dronca Eleonora, Niculae Alexandru, Cret Victoria, Silaghi Ciprian, Suciu Soimita   +6 more
doaj   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Paraoxonase 1 Activity in Endocrine Diseases

Endocrinology Research and Practice, 2011
Paraoxonase is an esterase bound to high-density lipoproteins which by metabolizing lipid peroxides, prevents their accumulation on low-density lipoproteins. It also hydrolyzes various organophosphorus compounds.
Özlem Tarçın, Dilek Gogas Yavuz
doaj   +2 more sources

Evaluation of Lipid metabolizing enzymes: Paraxonase1(PON1) and Lecithin Cholesterol acyltransferase (LCAT) activities in children with nephrotic syndrome

Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021
Background: The most common glomerular disorder in children is nephrotic syndrome, associated with high morbidity despite notable advances in its treatment. Many of the nephrotic syndrome complications, including the increased risk of atherosclerosis and
Raghad Jamal Ali , Rayah Sulaiman Baban , Shatha Hussain Ali   +2 more
doaj  

Surgical impact of laparoscopic and laparotomic elective ovariectomy on inflammatory and oxidative stress biomarkers in anestrus dogs

Veterinary Surgery, EarlyView.
Abstract Objective To compare the systemic inflammatory and oxidative stress responses after elective ovariectomy via open surgery (OPEN) or laparoscopy (LAP) in anestrus bitches. Study design Prospective, blinded, randomized clinical trial. Animals A total of 26 healthy bitches.
Alfonso Calabria, Chiara Del Prete, Maria Pia Pasolini, Veronica Palumbo, Maria Anna Nappo, Silvia Ammirati, Davide Ciccarelli, Fabiana Micieli, Michal Andrzej Kosior, Carmine Carbone, Natascia Cocchia   +10 more
wiley   +1 more source

Regulation of Hepatic Paraoxonase-1 Expression [PDF]

Journal of Lipids, 2012
Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate ...
openaire   +2 more sources

The importance of longitudinal evaluation using DAT‐SPECT in organophosphate‐induced toxic parkinsonism

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao, Yoichiro Kogoh, Hideki Funahashi, Yusei Yanoma, Minako Azuma, Yasushi Ishida, Yoji Hirano   +6 more
wiley   +1 more source

Identification of Protein Carbonyls (PCOs) in Canine Serum by Western Blot Technique and Preliminary Evaluation of PCO Concentration in Dogs With Systemic Inflammation

Frontiers in Veterinary Science, 2020
In people, serum Protein Carbonyls (PCOs) increase during oxidative stress (OS) due to oxidative damage to proteins. OS is often associated with inflammation and especially with sepsis, a condition hard to diagnose in veterinary medicine because reliable
Beatrice Ruggerone, Beatrice Ruggerone, Graziano Colombo, Saverio Paltrinieri, Saverio Paltrinieri   +4 more
doaj   +1 more source

The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Current bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
Liam A. O'Callaghan, Katie Powell, Russ Chess‐Williams, Catherine McDermott   +3 more
wiley   +1 more source