Results 31 to 40 of about 29,702,919 (203)
Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus [PDF]
Arthritis & Rheumatism, 2006 AbstractObjectiveLow serum paraoxonase 1 (PON1) activity determined with paraoxon as substrate has been found to be associated with coronary artery disease. This study was undertaken to examine the relationship of PON1 activity and genotype to risk of systemic lupus erythematosus (SLE).MethodsThe impact of 7 PON1 single‐nucleotide polymorphisms (SNPs ...
Laura M, Tripi +8 more
openaire +2 more sources
Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates [PDF]
Molecules, 2020 Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1). Carbamates were selected having a variety of applications: bambuterol and physostigmine are drugs, carbofuran is used as a pesticide ...
Anita Bosak +5 more
openaire +5 more sources
Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease [PDF]
Molecules, 2018 Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD.
Katarzyna Szczeklik +7 more
openaire +5 more sources
Paraoxonase and Paraoxon Detoxification (Pharmacokinetics).
, 1984 Paraoxon is the toxic metabolite of the widely used organophosphorous insecticide, parathion. Human serum paraoxonase, an enzyme which hydrolyzes paraoxon to two non-toxic products, is polymorphically distributed.
Butler, Edward Grant
core +5 more sources
Assessment of Serum Level of Paraoxonase-1 in Patients with Psoriasis Vulgaris [PDF]
, 2022 Background: Psoriasis is a chronic inflammatory dermatological disease with a strong genetic predisposition and autoimmune pathogenic traits. The hallmark of psoriasis is sustained inflammation that leads to uncontrolled keratinocyte proliferation and ...
Abo-Elsood, Karima Hussein Mohamed +3 more
core
Estudo dos polimorfismos PON1-192 e PON2-311 e atividade da enzima paroxonase em pacientes diabéticos tipo 2 [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004A paroxonase sérica humana (PON) é uma enzima localizada na HDL e está envolvida na detoxificação de ...
Catapan, Elisangela
core
Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative Diseases
, 2016 Decrease Paraoxonase-1 (PON-1) Activities in Neurodegenerative ...
Cervellati, Carlo +17 more
core +1 more source
Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021 Background: The most common glomerular disorder in children is nephrotic syndrome, associated with high morbidity despite notable advances in its treatment. Many of the nephrotic syndrome complications, including the increased risk of atherosclerosis and
Raghad Jamal Ali +2 more
doaj
Dietary cholesterol increases paraoxonase 1 enzyme activity
Journal of Lipid Research, 2012 HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk ...
Daniel S. Kim +10 more
doaj +1 more source