Results 31 to 40 of about 9,486 (169)
Paraoxonase 1 as an important antiatherogenic agent
Journal of Education, Health and Sport, 2019 The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol ...
Ewa Lidia Krzewicka-Romaniuk +3 more
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Correlation of Paraoxonase-1 with the Severity of Crohn’s Disease [PDF]
Molecules, 2018 Diagnostics of Crohn’s disease (CD) requires noninvasive biomarkers facilitating early detection and differentiation of the disease. Therefore, in this study, we aimed to determine the relationship between paraoxonase-1 (PON-1), the severity of CD, oxidative stress, and inflammation in CD.
Katarzyna Szczeklik +7 more
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Kinesiologia SlovenicaParaoxonase (PON) enzyme family (paraoxonase 1, 2 and 3) has antiatherosclerotic properties. The decreased PON1 enzyme activity (EA), PON1 level and PON1-L55M polymorphism (PON1P) are risk factors for atherosclerosis.
Ezgi Sevilmis +6 more
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Advanced Science, EarlyView.A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou +12 more
wiley +1 more source
Advanced Science, EarlyView.Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha +5 more
wiley +1 more source
Regulation of Hepatic Paraoxonase-1 Expression [PDF]
Journal of Lipids, 2012 Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme’s capability to decrease oxidative stress in atherosclerotic lesions and to attenuate ...
openaire +2 more sources
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021 Background: The most common glomerular disorder in children is nephrotic syndrome, associated with high morbidity despite notable advances in its treatment. Many of the nephrotic syndrome complications, including the increased risk of atherosclerosis and
Raghad Jamal Ali +2 more
doaj
Dietary cholesterol increases paraoxonase 1 enzyme activity
Journal of Lipid Research, 2012 HDL-associated paraoxonase 1 (PON1) activity has been consistently associated with cardiovascular and other diseases. Vitamins C and E intake have previously been positively associated with PON1 in a subset of the Carotid Lesion Epidemiology and Risk ...
Daniel S. Kim +10 more
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Journal of the Science of Food and Agriculture, EarlyView.Abstract Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuronal loss driven by oxidative stress and inflammation. Quercetin, a dietary flavonoid with established antioxidant and anti‐inflammatory properties, has emerged as a potential neuroprotective agent.
In Ho Cho +6 more
wiley +1 more source
Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents
Romanian Journal of Laboratory Medicine, 2015 Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for ...
Sandor Raluca +6 more
doaj +1 more source