Results 41 to 50 of about 9,486 (169)

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

Association between pesticide exposure and paraoxonase-1 (PON1) polymorphisms, and neurobehavioural outcomes in children: a systematic review

Systematic Reviews, 2020
Environmental factors such as pollution, pesticide exposure and socio-demographic location have been implicated as a pressure capable of altering genetic make-up.
Nkosinathi Banhela, Pragalathan Naidoo, Saloshni Naidoo   +2 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Paraoxonase 1 Activity in Endocrine Diseases

Endocrinology Research and Practice, 2011
Paraoxonase is an esterase bound to high-density lipoproteins which by metabolizing lipid peroxides, prevents their accumulation on low-density lipoproteins. It also hydrolyzes various organophosphorus compounds.
Özlem Tarçın, Dilek Gogas Yavuz
doaj   +2 more sources

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 10, October 2026.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Seminal Extracellular Vesicles as Molecular Modulators of Male Reproductive Function

Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.
ABSTRACT Extracellular vesicles (sEVs) contained in seminal plasma (SP) maintain, in concert with free SP‐components (proteins, hormones, cytokines, metabolites and antioxidants) under an endocrine umbrella the functional in vivo homeostasis of ejaculated spermatozoa. The sEVs define a generic mixture of nanovesicles delivered by male epithelial cells,
Heriberto Rodriguez‐Martinez, Jordi Roca, Fernando Peña Vega, Emilio A. Martinez   +3 more
wiley   +1 more source

The paraoxonase 1, paraoxonase 2 and paraoxonase 3 in humans

Biochemia medica, 2011
The paraoxonase gene family in humans includes three members: pon1, pon2 and pon3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (
Rumora, Lada, Barišić, Karmela, Grdić Rajković, Marija   +2 more
openaire   +1 more source

The paraoxonase 1, 2 and 3 in humans

Biochemia Medica, 2011
The paraoxonase gene family in humans includes three members: PON1, PON2 and PON3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (
Grdic Rajkovic, Marija, Rumora, Lada, Barisic, Karmela   +2 more
openaire   +5 more sources

The human paraoxonase‐1 phenotype modifies the effect of statins on paraoxonase activity and lipid parameters [PDF]

British Journal of Clinical Pharmacology, 2008
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • It has been suggested that the human paraoxonase‐1 (PON1) genotype is an important determinant of the therapeutic response given to statin treatment.• It is also known that the PON1 activity status is a better predictor of coronary heart disease risk than any of the known PON1 genotypes.• Our goal was to ...
Hossein Z, Mirdamadi, Ferenc, Sztanek, Zoltan, Derdak, Ildiko, Seres, Mariann, Harangi, György, Paragh   +5 more
openaire   +2 more sources

Environmental Pesticide Exposure in the Etiology of Pediatric Brain Tumors and Leukemia: A Scoping Review of Epidemiological Studies

International Journal of Cancer, Volume 159, Issue 6, Page 1360-1384, 15 September 2026.
ABSTRACT Pediatric cancer is a significant cause of morbidity and mortality in children. The etiologies of pediatric cancer are largely unknown, but environmental pesticide exposures are likely to contribute. Chronic low‐dose exposure to pesticide mixtures through drinking water is a growing concern in agricultural communities.
Grace N. VanDeSteeg, Alyssa R. Russum, Matthew R. Sandbulte, Eleanor G. Rogan, Martha G. Rhoades   +4 more
wiley   +1 more source