Results 171 to 180 of about 226,005 (247)

Intestinal γδ T17-IL-17A signaling disrupts hippocampal mitophagy in stress-induced depression and is restored by arketamine. [PDF]

J Neuroinflammation
Han M, Xie B, Yu Y, Xu D, Shi Y, Xu M, Wu Y, Zhang Y, Wen X, Wang X, Zhen Z, Zhang X, Sun X, Yuan Y, Shang Y, Yuan S, Hashimoto K, Zhang J.   +17 more
europepmc   +1 more source

Decreased PTGES2 Farnesylation in Granulosa Cells Compromises PGE2‐Dependent Cumulus Expansion and Oocyte Maturation During Ovarian Aging

Aging Cell, Volume 25, Issue 2, February 2026.
A schematic showing decreased PTGES2 farnesylation in granulosa cells compromises PGE2‐dependent cumulus expansion and oocyte maturation during ovarian aging. In young ovaries, PTGES2 farnesylation of GCs regulates the process of cumulus expansion and oocyte maturation by facilitating PGE2 production.
Sainan Zhang, Jiahui Qi, Chuanming Liu, Huidan Zhang, Bichun Guo, Die Wu, Yicen Liu, Xin Zhen, Yang Zhang, Nannan Kang, Jidong Zhou, Guijun Yan, Chaojun Li, Lijun Ding, Haixiang Sun   +14 more
wiley   +1 more source

The many faces of p97/Cdc48 in mitochondrial homeostasis. [PDF]

Essays Biochem
Ram J, Glickman MH.
europepmc   +1 more source

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK‐ULK1‐Mediated Mitochondrial Quality Control

Aging Cell, Volume 25, Issue 2, February 2026.
Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas, Elizabeth R. M. Zunica, Elizabeth C. Heintz, Charles L. Hoppel, Cristal M. Hill, Christopher D. Morrison, Christopher L. Axelrod, Gangarao Davuluri, John P. Kirwan   +8 more
wiley   +1 more source

Near field optical visualization of the nanoscale phase percolation dynamics of a VO₂ oscillator. [PDF]

Nat Commun
Tiwari K, Wang Z, Xie Y, Gopi AK, Jeon JC, Xiao K, Parkin SSP.   +6 more
europepmc   +1 more source

Unveiling the Crucial Nexus: Mitochondrial Quality Control as a Central Driver in Metabolic Dysfunction‐Associated Steatotic Liver Disease Pathogenesis

Cell Proliferation, Volume 59, Issue 2, February 2026.
Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu, Junqi Wang, Nan Lu, Zhijiang Guo, Sang‐Bing Ong, Yong Gao, Hao Zhou, Xing Chang, Miao Meng   +8 more
wiley   +1 more source

Zinc‐Mediated Lysosomal Destabilization Links Mitochondrial Damage to Neuronal Death in a Cellular MPP+ Model of Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
When mitochondria are damaged by MPP+, they produce excess reactive oxygen species (ROS) and release zinc (Zn2+) inside the cell. This surge in zinc overwhelms lysosomes—the cell's major zinc‐buffering organelles—causing their membranes to break down. Leaking lysosomal enzymes then trigger neuronal death. Treatments that reduce ROS, bind zinc, or block
Hyun‐Seung Lee, Sun‐Ah Kang, Jae‐Won Eom, Min Seong Kim, Ji‐Soo Kim, Yang‐Hee Kim   +5 more
wiley   +1 more source

Mitophagy as a therapeutic target for exercise-induced fatigue: modulation by natural compounds and mechanistic insights. [PDF]

Front Physiol
Yu M, Jiang X, Zhang Y, Zhang W, Wang T, Wang J, Shao J, Zhang L, Sun Y, Meng X, Li X, Liu X.   +11 more
europepmc   +1 more source

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

Experimental Physiology, Volume 111, Issue 2, Page 489-500, 1 February 2026.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li, Yiying Fan, Shaik Althaf Hussain   +2 more
wiley   +1 more source

SIRT3 attenuates AGEs-induced senescence in human granulosa cells through enhancing mitophagy. [PDF]

Cell Biol Toxicol
Li S, Tang M, Zhu S, Zhang Z, Cao Y, Xue R.   +5 more
europepmc   +1 more source