Results 181 to 190 of about 226,162 (289)

Skeletal muscle mitochondrial marker responses to a single bout and 6 weeks of high load versus high volume resistance training in previously trained men

Experimental Physiology, EarlyView.
Abstract The effects of high‐load (HL) versus high‐volume (HV) resistance training (RT) on various molecular outcomes are similar. However, mitochondrial responses remain understudied. Therefore, the purpose of this study was to interrogate mitochondrial mRNA and protein responses to acute and chronic HL versus HV RT.
Breanna Mueller, Carlton D. Fox, Hailey A. Parry, Paulo H. C. Mesquita, Christopher G. Vann, Bradley A. Ruple, Casey L. Sexton, Joshua S. Godwin, Mason M. McIntosh, Darren T. Beck, Kaelin C. Young, Stuart M. Phillips, Andreas N. Kavazis, Michael D. Roberts   +13 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but not histological features of Duchenne muscular dystrophy in mice. [PDF]

Sci Rep
Reynaud O, Ayoub MB, Leduc-Gaudet JP, Cefis M, Lussier MP, Hussain SN, Gouspillou G.   +6 more
europepmc   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, EarlyView.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

The Effect of Mechanical Loading on Mitophagy in Aged Myoblasts. [PDF]

Cells
Tolis E, Chatzinikita E, Moustogiannis A, Giannopoulos A, Maridaki M, Koutsilieris M, Philippou A.   +6 more
europepmc   +1 more source

Patient‐ and caregiver‐reported barriers to chemotherapy in nine sub‐Saharan African countries: A cross‐sectional survey among population‐based registries

International Journal of Cancer, Volume 158, Issue 10, Page 2684-2696, 15 May 2026.
What's New? Increasing cancer incidence and mortality in low‐ and middle‐income countries has heightened concerns about limited resources and barriers to care. This challenge is particularly urgent in Sub‐Saharan Africa (SSA), where cancer rates are rising sharply. Here, data from population‐based cancer registries in nine SSA countries was assessed to
Tamara König, Nikolaus Christian Simon Mezger, Ole Stoeter, Phoebe Mary Amulen, Margaret Borok, Gladys C. Chesumbai, Moudiongui MBoungou Dimitry, Ima‐Obong Ekanem, Adugna Fekadu, Bakarou Kamaté, William Muller, Alex Alain Kabena Nzambikolo, Abidemi Omonisi, Furaha Serventi, Markus Wallwiener, Biying Liu, Donald Maxwell Parkin, Pablo Sandro Carvalho Santos, Eva Johanna Kantelhardt, Eric Sven Kroeber   +19 more
wiley   +1 more source

Parkin deficiency impairs female fertility, oocyte development, fertilization and mitochondrial function in mice. [PDF]

NPJ Aging
Volovsky M, Rodríguez-Eguren A, Ergun Y, Yildirim RM, Sahin GN, Garcia Milian R, Mehta S, Turanli L, Cervelló I, Scott R, Seli E.   +10 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models. [PDF]

J Clin Invest
Song P, Chen C, Franchini R, Duong B, Wang YZ, Coukos R, Xie Z, Savas JN, Zhou Y, Bertoldi M, Surmeier DJ, Parisiadou L, Krainc D.   +12 more
europepmc   +1 more source