Advanced Science, Volume 13, Issue 19, 2 April 2026.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
FDA-approved PDE4 inhibitors alleviate the dominant toxicity of ALS-FTD-associated CHCHD10<sup>S59L</sup> in <i>Drosophila</i> and human cells. [PDF]
iScienceMaitra S +4 more
europepmc +1 more source
The Brain‐Gut Axis in Parkinson's Disease Pathology
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya +1 more
wiley +1 more source
Journal of Engineering Education, Volume 115, Issue 2, April 2026.Abstract Background The experiences of the disabled community are notably absent from engineering education scholarship, with existing research often treating this group as a monolith. Intersectionality provides a critical framework for addressing this gap, illuminating the complexities of disability within ableist contexts by focusing on how ...
Rachel Figard +3 more
wiley +1 more source
Mitochondrial Homeostasis in Diabetic Cardiomyopathy: From Dysfunction to Therapeutic Strategies. [PDF]
Antioxidants (Basel)Huang Y +4 more
europepmc +1 more source
Neuroprotective Effects of Cerium Oxide Nanoparticles During Spaceflight
Small Science, Volume 6, Issue 4, April 2026.Cerium oxide nanoparticles are investigated as antioxidant neuroprotectants for neurons exposed to the spaceflight environment aboard the International Space Station. The treatment preserves neuronal morphology, supports neurite outgrowth, and stabilizes gene networks involved in antioxidant defense, mitochondrial function, and dopamine metabolism ...
Alessio Carmignani +13 more
wiley +1 more source
Parkin Deficiency Impairs ER-Mitochondria Associations and calcium homeostasis via IP3R-Grp75-VDAC1 Complex. [PDF]
Int J Biol SciXue NJ +10 more
europepmc +1 more source
Description of veterinary events and risk factors for fatality in National Hunt flat racing Thoroughbreds in Great Britain (2000-2013) [PDF]
, 2017 Altman +16 more
core +2 more sources
Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.ABSTRACT Aim One of the effects of Cistanche herb is described in the Chinese Pharmacopoeia as for lack of strength in muscles and bones. However, concrete evidence of this herb for muscle strength has been hardly reported. The present study aimed to clarify the effects of 30% ethanolic extract of Cistanche tubulosa fleshy stem on muscle strength and ...
Jae‐Won Jung, Chihiro Tohda
wiley +1 more source
<i>Listeria monocytogenes</i> invasion in goat brain tissues: mechanisms of blood-brain barrier disruption and regulation of apoptosis and autophagy. [PDF]
Front MicrobiolHu Y +10 more
europepmc +1 more source