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No Parkin Zone: Mitophagy without Parkin
Trends in Cell Biology, 2018Mitochondria are essential highly dynamic organelles that provide the necessary energy for a variety of different processes, such as survival, proliferation, and migration. In order to maintain an intact mitochondrial network, cells have developed quality control systems that allow the removal of damaged or superfluous mitochondria by selective ...
Elodie, Villa +2 more
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Parkin and mitochondrial signalling
Cellular Signalling, 2023Aging, toxic chemicals and changes to the cellular environment are sources of oxidative damage to mitochondria which contribute to neurodegenerative conditions including Parkinson's disease. To counteract this, cells have developed signalling mechanisms to identify and remove select proteins and unhealthy mitochondria to maintain homeostasis.
Elizabeth M, Connelly +2 more
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Parkinsonism & Related Disorders, 2009
The search for genetic mutations responsible for familial forms of Parkinson's disease (PD) has identified several genes and loci. Mutations in the parkin gene are linked to autosomal recessive juvenile parkinsonism. The genetic forms of PD are uncommon, but gene therapy targeting alpha-synuclein, parkin, or other pathways may be also applicable for ...
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The search for genetic mutations responsible for familial forms of Parkinson's disease (PD) has identified several genes and loci. Mutations in the parkin gene are linked to autosomal recessive juvenile parkinsonism. The genetic forms of PD are uncommon, but gene therapy targeting alpha-synuclein, parkin, or other pathways may be also applicable for ...
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Arrestin‐3 binds parkin and enhances parkin‐dependent mitophagy
Journal of NeurochemistryAbstract Arrestins were discovered for their role in homologous desensitization of G‐protein‐coupled receptors (GPCRs). Later non‐visual arrestins were shown to regulate several signaling pathways. Some of these pathways require arrestin binding to GPCRs, the regulation of others is receptor independent.
Chen Zheng +4 more
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Parkin-associated Parkinson’s disease
Cell and Tissue Research, 2004Mutations in the PARK2 gene coding for parkin cause autosomal recessive juvenile parkinsonism (AR-JP), a familial form of Parkinson's disease (PD). Parkin functions as an E3 ubiquitin ligase, and loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of AR-JP.
Rainer, von Coelln +2 more
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Parkin and Parkinsonʼs disease
Current Opinion in Neurology, 2001Parkin is the causative gene for an autosomal recessive form of Parkinson's disease. The gene was discovered in 1998. The parkin gene is a novel gene containing 12 exons spanning over 1.5 Mb and encodes a protein of 465 amino acids with a molecular mass of approximately 52,000 M(r). Various deletion mutations and point mutations have been discovered in
Y, Mizuno +4 more
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