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Transcranial sonography in parkinsonian disorders
2021Parkinson's disease is extremely difficult to diagnose, given that no test provides conclusive evidence for the disease. Many patients in the early stages of the disease have very few symptoms or experience symptoms that overlap with other conditions that resemble Parkinson's disease, known as parkinsonian disorders.
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Caribbean parkinsonism and other atypical Parkinsonian disorders
Parkinsonism & Related Disorders, 2004Atypical parkinsonism (AP) is a term applied to disorders characterized by parkinsonism that evolves rapidly, with poor or transient response to levodopa, or has other associated features such as early falls and postural instability, early autonomic failure, supranuclear gaze palsy, pyramidal or cerebellar signs, alien hand syndrome or severe ideomotor
Eduardo, Tolosa +2 more
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Glabellar and palmomental reflexes in parkinsonian disorders
Neurology, 2004The authors examined the glabellar reflex and the palmomental reflex in 100 subjects, including patients with Parkinson disease (n = 41), patients with progressive supranuclear palsy (n = 12), patients with multiple system atrophy (n = 7), and healthy, age-matched, controls (n = 40).
Harris, Brodsky +3 more
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Recent advances in atypical parkinsonian disorders
Current Opinion in Neurology, 1999Recent advances in epidemiologic, diagnostic, pathologic, and management aspects of atypical parkinsonian disorders are reviewed and placed in perspective. The implications of considering progressive supranuclear palsy and corticobasal degeneration as tauopathies, and multiple system atrophy and dementia with Lewy bodies as alpha-synucleopathies are ...
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Differentiating Parkinson's Disease from Other Parkinsonian Disorders
Seminars in Neurology, 2007In 1817, James Parkinson formally described the shaking palsy that is now known as idiopathic Parkinson's disease (PD). Symptoms of PD, however, existed for thousands of years before that time. Descriptions evolved significantly until the term PARKINSONISM was eventually coined to describe neurologic disorders characterized by the presence of tremor ...
Maria V, Alvarez +2 more
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Deep brain stimulation for parkinsonian gait disorders
Journal of Neurology, 2008The cardinal motor manifestation of Parkinson's disease (PD) is being treated with greater and greater efficacy with both newer medications as well as both subthalamic nucleus (STN) and globus pallidus internus (GPI) deep brain stimulation (DBS). The burden of disease is shifting towards the non-dopaminergic disease manifestations including gait and ...
Andres M, Lozano, Brian J, Snyder
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Quantitative susceptibility mapping differentiates between parkinsonian disorders
Parkinsonism & Related Disorders, 2017It is often challenging to clinically distinguish between Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Quantitative susceptibility mapping (QSM) is an accurate indirect method for estimating brain iron levels in vivo. This method has yet to be applied in atypical parkinsonism. We aimed to investigate
Henrik Sjöström +3 more
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The auditory startle reaction in parkinsonian disorders
Movement Disorders, 2001The auditory startle reaction to an unexpected loud stimulus is regarded as a brainstem reflex originating in the nucleus reticularis pontis caudalis and being distributed up the brainstem and down the spinal cord along slowly conducting pathways. Auditory startle responses (ASR) have been reported absent or reduced in progressive supranuclear palsy ...
M, Kofler +8 more
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Cerebrospinal Fluid Levels of Neurogranin in Parkinsonian Disorders
Movement Disorders, 2019AbstractBackgroundCSF concentration of neurogranin has been suggested as a biomarker for synapse dysfunction.ObjectivesTo investigate CSF neurogranin in parkinsonian disorders compared to controls and Alzheimer's disease and the possible correlations between neurogranin and cognitive and motor impairment.MethodsWe included 157 patients with PD, 29 with
Hall, S +7 more
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Neuropathology of Atypical Parkinsonian Disorders
2005Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1, 2, 3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical ...
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