Results 31 to 40 of about 97,797 (263)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
IEEE Access, 2019 Model predictive control (MPC) is advantageous for designing an electrical vehicle path-tracking controller, but the high computational complexity, mathematical problem, and parameterization challenge adversely affect the control performance.
Bing Zhang +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hybrid Adaptive Sliding Mode Controller for Path Tracking of Wheeled Mobile Robot in Uncertainty
Ain Shams Engineering JournalIn this paper robust kinematic based adaptive sliding mode controller (KASMC) and dynamic based adaptive sliding mode controller (DASMC) are proposed for path tracking of wheeled-mobile-robot (WMR).
Madhu Sudan Das +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Safety research on stabilization of autonomous vehicles based on improved-LQR control
AIP Advances, 2022 Mediating the divergent interest of vehicle stability and strengthened path tracking performance when aiming at the design of a path tracking controller for autonomous vehicles is a challenging issue.
Hao Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Predicting and tracking internet path changes [PDF]
Proceedings of the ACM SIGCOMM 2011 conference, 2011 This paper investigates to what extent it is possible to use traceroute-style probing for accurately tracking Internet path changes. When the number of paths is large, the usual traceroute based approach misses many path changes because it probes all paths equally.
Cunha, Italo +3 more
openaire +4 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source