Results 31 to 40 of about 97,550 (264)

Electrical Vehicle Path Tracking Based Model Predictive Control With a Laguerre Function and Exponential Weight

IEEE Access, 2019
Model predictive control (MPC) is advantageous for designing an electrical vehicle path-tracking controller, but the high computational complexity, mathematical problem, and parameterization challenge adversely affect the control performance.
Bing Zhang, Changfu Zong, Guoying Chen, Bangcheng Zhang   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Steering control based on model predictive control for obstacle avoidance of unmanned ground vehicle

Measurement + Control, 2020
In this paper, a strategy based on model predictive control consisting of path planning and path tracking is designed for obstacle avoidance steering control problem of the unmanned ground vehicle.
Chaofang Hu, Lingxue Zhao, Lei Cao, Patrick Tjan, Na Wang   +4 more
doaj   +1 more source

Safety research on stabilization of autonomous vehicles based on improved-LQR control

AIP Advances, 2022
Mediating the divergent interest of vehicle stability and strengthened path tracking performance when aiming at the design of a path tracking controller for autonomous vehicles is a challenging issue.
Hao Li, Peiqing Li, Likang Yang, Jun Zou, Qipeng Li   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Hybrid Adaptive Sliding Mode Controller for Path Tracking of Wheeled Mobile Robot in Uncertainty

Ain Shams Engineering Journal
In this paper robust kinematic based adaptive sliding mode controller (KASMC) and dynamic based adaptive sliding mode controller (DASMC) are proposed for path tracking of wheeled-mobile-robot (WMR).
Madhu Sudan Das, Usha Rani Gogoi, Sanjoy Mandal   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Minimum time control for path tracking problem of intelligent vehicle handling in inverse dynamics

Advances in Mechanical Engineering
The continuous development of vehicle intelligence and electronic technology has greatly promoted the vigorous development of the automotive industry.
Shanshan Guo, Yingjie Liu
doaj   +1 more source