Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune ...
Guang Han Ong +3 more
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Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1 [PDF]
Nature Communications, 2022 Pattern-triggered immunity is activated by recognition of microbe-derived structures by host pattern recognition receptors. Here the authors use a genotype-by sequencing approach to show that bacterial translation initiation factor 1 triggers PTI in ...
Li Fan +15 more
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Avian Pattern Recognition Receptor Sensing and Signaling [PDF]
Veterinary Sciences, 2020 Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms.
Sabari Nath Neerukonda, Upendra Katneni
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NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages. [PDF]
Sci Immunol, 2023 Endotoxin - bacterial lipopolysaccharide (LPS) - is a driver of the lethal infection sepsis through activation of innate immune responses. When delivered to the cytosol of macrophages, LPS (cLPS) induces the assembly of an inflammasome that contains ...
Rojas-Lopez M +8 more
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Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition [PDF]
eLife, 2022 As a first step in innate immunity, pattern recognition receptors (PRRs) recognize the distinct pathogen and herbivore-associated molecular patterns and mediate activation of immune responses, but specific steps in the evolution of new PRR sensing ...
Simon Snoeck +5 more
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Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease. [PDF]
Gastroenterology, 2022 IBD is characterized by defects in epithelial function and dysregulated inflammatory signaling by lamina propria mononuclear cells including macrophages and dendritic cells in response to microbiota.
Abraham C, Abreu MT, Turner JR.
europepmc +2 more sources
Regulation of pattern recognition receptor signaling by palmitoylation [PDF]
iScienceSummary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological ...
Xiaocui Li +5 more
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Pattern recognition receptor ligand-induced differentiation of human transitional B cells. [PDF]
PLoS ONE, 2022 B cells represent a critical component of the adaptive immune response whose development and differentiation are determined by antigen-dependent and antigen-independent interactions.
Jourdan K P McMillan +2 more
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The activating receptor NKG2D is an anti-fungal pattern recognition receptor [PDF]
Nature CommunicationsNKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous
Yoav Charpak-Amikam +11 more
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RIG-I: a multifunctional protein beyond a pattern recognition receptor
Protein & Cell, 2017 It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs.
Xiao-xiao Xu +5 more
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