Results 21 to 30 of about 633,152 (295)
Japanese Journal of Clinical Immunology, 2011 Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi +2 more
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Pattern Recognition Receptors and Autophagy [PDF]
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control immune responses.
Oh, JE Oh, Ji Eun +1 more
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Frontiers in Immunology, 2023 Surgery or radiation therapy is nearly universally applied for pediatric solid tumors. In many cases, in diverse tumor types, distant metastatic disease is present and evades surgery or radiation.
Emily P. Vonderhaar +7 more
doaj +1 more source
The innate immune receptor Nlrp12 suppresses autoimmunity to the retina
Journal of Neuroinflammation, 2022 Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined.
Ellen J. Lee +6 more
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Cellular and Molecular Gastroenterology and Hepatology, 2022 Background and aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).
Hai-Yun Li +9 more
doaj +1 more source
Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19
Viruses, 2022 The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented morbidity and mortality worldwide.
Qi Liu +4 more
doaj +1 more source
Autophagy, 2020 DDX58/RIG-I, is a critical pattern recognition receptor for viral RNA, which plays an essential role in antiviral immunity. Its posttranslational modifications and stability are tightly regulated to mediate the moderate production of type I IFN to ...
Huifang Xian +4 more
semanticscholar +1 more source
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
doaj +1 more source
Cells, 2021 Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy.
Yulin Ouyang +13 more
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Pattern Recognition Receptors and Inflammation [PDF]
Cell, 2010 Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors.
Takeuchi, Osamu, Akira, Shizuo
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