Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. [PDF]
PLoS ONE, 2014 Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption.
Roy L Sutliff +15 more
doaj +14 more sources
Pendrin inhibition is associated with protective effect of prone positioning in a ventilator-induced lung injury mouse model [PDF]
Scientific ReportsPendrin (SLC26A4), a transmembrane anion exchanger, is upregulated in inflammatory airway diseases. In this study, we analyzed the role of pendrin expression in a ventilator-induced acute lung injury (VILI) animal model. VILI was induced in the supine or
Ji Soo Choi +7 more
doaj +2 more sources
IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. [PDF]
PLoS ONE, 2014 The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide ...
Kelly M Adams +7 more
doaj +6 more sources
Lmx1a is essential for marginal cell differentiation and stria vascularis formation [PDF]
Frontiers in Cell and Developmental BiologyThe transcription factor Lmx1a is widely expressed during early inner ear development, and mice lacking Lmx1a expression exhibit fusion of cochlear and vestibular hair cells and fail to form the ductus reuniens and the endolymphatic sac.
Justine M. Renauld +14 more
doaj +2 more sources
Mechanism of anion exchange and small-molecule inhibition of pendrin [PDF]
Nature CommunicationsPendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO3 −) exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the kidney, lung, and cochlea. Pendrin also exports iodide (I−) in the thyroid gland. Pendrin
Lie Wang +5 more
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Metabolic alkalosis in cystic fibrosis: from vascular volume depletion to impaired bicarbonate excretion [PDF]
Frontiers in EndocrinologyCystic fibrosis (CF) is the most common life-threatening genetic disease in the United States and among people of European descent. Despite the widespread distribution of the cystic fibrosis transmembrane conductance regulator (CFTR) along kidney tubules,
Manoocher Soleimani, Manoocher Soleimani
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Functional interplay between CFTR and pendrin: physiological and pathophysiological relevance
Frontiers in Bioscience-Landmark, 2022 The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume.
Grazia Tamma, Silvia Dossena
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Physiological Reports, 2022 SLC26A4/Pendrin is the major electroneutral Cl−/HCO3− exchanger of the apical membrane of the Type B intercalated cell (IC) of the connecting segment (CNT) and cortical collecting duct (CCD).
John F. Heneghan +7 more
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Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium. [PDF]
, 2015 The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and ...
Choi, Jae Young +8 more
core +8 more sources
Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger
Nature Communications, 2023 Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure ...
Qianying Liu +17 more
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