Results 11 to 20 of about 3,909 (203)

Sgk1 Sensitive Pendrin Expression in Murine Platelets [PDF]

Cellular Physiology and Biochemistry, 2013
Background: The anion exchanger pendrin (SLC26A4) is required for proper development of the inner ear, and contributes to iodide organification in thyroid glands as well as anion transport in various epithelia, such as airways and renal tubules.
Lisann Pelzl, Hajar Fakhri, Anja T. Umbach, Meinrad Gawaz, Markus Paulmichl, Florian Lang   +5 more
doaj   +4 more sources

Developmental Expression of Membrane Pumps and Ion Channels in Human Vestibular Endolymph Homeostasis. [PDF]

Dev Neurobiol
ABSTRACT The expression patterns of key membrane pumps and ion channels involved in endolymph cycling have been studied in the rodent inner ear and the developing and adult human cochlea. However, little is known about their expression during the development of the human vestibular system.
van Beelen ESA, van der Valk WH, de Groot JCMJ, van Benthem PPG, Locher H.   +4 more
europepmc   +2 more sources

SLC26A4 C.317C > A Variant: Functional Analysis and Patient-Derived Induced Pluripotent Stem Line Development. [PDF]

Mol Genet Genomic Med
We identified compound heterozygous variants in the SLC26A4 gene, c.919‐2A > G and c.317C > A, and studied how the c.317C > A variant affects Pendrin expression and function. We successfully induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells (PBMCs) of the proband.
Li Y, Sun T, Hu S, Xu H, Zhang T, Liu J, Lu S, Wang B, Dan G.   +8 more
europepmc   +2 more sources

La pendrine [PDF]

médecine/sciences, 2010
Les mutations inactivatrices du gene de la pendrine sont responsables d’une pathologie associant des troubles de la thyroide et de l’oreille interne. Cependant, il est rapidement apparu apres sa decouverte que l’echangeur d’anions code par ce gene joue un role essentiel dans le rein.
Alain Doucet, Dominique Eladari
openaire   +1 more source

Pendrin Function in Airway Epithelia [PDF]

Cellular Physiology and Biochemistry, 2011
The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also expressed in the bronchial epithelium following exposure to the T(H)2-type cytokines, interleukin (IL)-4 and IL-13.
Charity, Nofziger, Silvia, Dossena, Shoichi, Suzuki, Kenji, Izuhara, Markus, Paulmichl   +4 more
openaire   +2 more sources

Transcriptional Regulation of the Pendrin Gene [PDF]

Cellular Physiology and Biochemistry, 2011
Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively.
Julia, Rozenfeld, Edna, Efrati, Lior, Adler, Osnat, Tal, Stephen L, Carrithers, Seth L, Alper, Israel, Zelikovic   +6 more
openaire   +2 more sources

Hypokalemia and Pendrin Induction by Aldosterone [PDF]

Hypertension, 2017
Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na + channel, Na + -Cl − cotransporter, and Cl − /HCO 3 − exchanger pendrin are the major mediators of Na-Cl ...
Ning, Xu, Daigoro, Hirohama, Kenichi, Ishizawa, Wen Xiu, Chang, Tatsuo, Shimosawa, Toshiro, Fujita, Shunya, Uchida, Shigeru, Shibata   +7 more
openaire   +2 more sources

Methylation of the Human Pendrin Promoter [PDF]

Cellular Physiology and Biochemistry, 2011
Inspection of the nucleotide sequence of the human pendrin promoter revealed the presence of a CpG island. We investigated the ability of IL-4 to stimulate pendrin message expression in two separate cell lines: the NCI-H292 lung epithelial cell line and the human embryonic kidney (HEK)-Blue cell line.
Adam, Lee, Charity, Nofziger, Silvia, Dossena, Simone, Vanoni, Robert, Diasio, Markus, Paulmichl   +5 more
openaire   +2 more sources

Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney

Frontiers in Molecular Biosciences, 2022
Background: Several members of the SLC26A family of transporters, including SLC26A3 (DRA), SLC26A5 (prestin), SLC26A6 (PAT-1; CFEX) and SLC26A9, form multi-protein complexes with a number of molecules (e.g., cytoskeletal proteins, anchoring or adaptor ...
Jie Xu, Jie Xu, Sharon Barone, Sharon Barone, Sharon Barone, Mujan Varasteh Kia, L. Shannon Holliday, Kamyar Zahedi, Kamyar Zahedi, Kamyar Zahedi, Manoocher Soleimani, Manoocher Soleimani, Manoocher Soleimani   +12 more
doaj   +1 more source

Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting. [PDF]

PLoS ONE, 2016
Contribution of salt wasting and volume depletion to the pathogenesis of hypercalciuria and hyperphosphaturia is poorly understood. Pendrin/NCC double KO (pendrin/NCC-dKO) mice display severe salt wasting under basal conditions and develop profound ...
Manoocher Soleimani, Sharon Barone, Jie Xu, Saeed Alshahrani, Marybeth Brooks, Francis X McCormack, Roger D Smith, Kamyar Zahedi   +7 more
doaj   +1 more source