Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]
, 2019 Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid +6 more
core +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
Expressivity and Generalization: Fragment-Biases for Molecular GNNs [PDF]
International Conference on Machine Learning. 2024. OralAlthough recent advances in higher-order Graph Neural Networks (GNNs) improve the theoretical expressiveness and molecular property predictive performance, they often fall short of the empirical performance of models that explicitly use fragment information as inductive bias.
arxiv
Peptide Segment Separation by Tertiary Peptide Bonds. Synthesis and Conformational Analysis of Cross-Linked Polystyrene Resin-Bound Human Proinsulin C-Peptide Fragments [PDF]
, 1989 Mitsuaki Narita +2 more
openalex +1 more source
Cardiac Organoid Model Inspired Micro‐Robot Smart Patch to Treat Myocardial Infarction
Advanced Materials, EarlyView.The heart organoid model exhibits the acidic microenvironment characteristic of myocardial infarction, which emerges as a pivotal force propelling the movement of micro‐robots. These micro‐robots, administered through microneedles, can penetrate deep into the tissue, effectively delivering therapeutic payloads to facilitate heart repair.
Fangfang Wang +12 more
wiley +1 more source
Reconstruction of peptidyltransferase activity on 50S and 70S ribosomal particles by peptide fragments of protein L16 [PDF]
, 1987 R.M. Baxter +3 more
openalex +1 more source
Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction
Advanced Materials, EarlyView.We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin +17 more
wiley +1 more source
Identification of DNA restriction fragments of corynebacteriophage β corresponding to hypotoxic peptides of diphtheria toxin [PDF]
, 1983 M J Bjorn +2 more
openalex +1 more source
Materials Advances in Devices for Heart Disease Interventions
Advanced Materials, EarlyView.This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra +11 more
wiley +1 more source