Results 41 to 50 of about 455,908 (138)

Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]

, 2013
Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason, Cuijpers, Sabine A. G., Davletov, Bazbek, Ferrari, Enrico, Niranjan, Dhevahi, O'Brien, John A.   +5 more
core   +1 more source

Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant\ue2\u80\u93anticoagulant equilibrium toward thrombosis [PDF]

, 2017
Blood coagulation is a finely regulated physiological process culminating with the factor Xa (FXa)-mediated conversion of the prothrombin (ProT) zymogen to active -thrombin (T).
Acquasaliente, Laura, Artusi, Ilaria, De Filippis, Vincenzo, Frasson, Roberta, Peterle, Daniele, Pontarollo, Giulia   +5 more
core   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho, Andersson, Auger, Baeten, Bella, Bettina Sehnert, Brunsberg, Burkhardt, Burkhardt, Bäcklund, Caspi, Chang, Chapuy-Regaud, Collaborative Computational Project, Number 4, DeLano, Dyson, Emsley, Emsley, Emsley, Estelle Bajtner, Foulquier, Girbal-Neuhauser, Giudicelli, Grab, Guy Serre, Harald Burkhardt, Hill, Hill, Hoffmann, Hüseyin Uysal, Kabsch, Kanazawa, Kidd, Krissinel, Kuhn, Kutty S. Nandakumar, Lefranc, Marjolein M.G.M. Thunnissen, Masson-Bessière, Masson-Bessière, Michaëlsson, Molberg, Murshudov, Nair, Nandakumar, Rantapää-Dahlqvist, Read, Reparon-Schuijt, Rikard Holmdahl, Robert Bockermann, Rosloniec, Schellekens, Schellekens, Schulte, Schwab, Stanfield, Stetefeld, Tarcsa, Uysal, van der Helm-van Mil, Vander Cruyssen, von Delwig, Vossenaar, Vossenaar, Vossenaar, Vossenaar, Winn, Yousfi Monod, Zong, Åke Engström   +69 more
core   +2 more sources

Dissociation channel dependence on peptide size observed in electron capture dissociation of tryptic peptides

, 2011
International audienceElectron capture dissociation (ECD) of a series of five residue peptides led to the observation that these small peptides did not lead to the formation of the usual c/z ECD fragments, but to a, b, y and w fragments.
Chamot-Rooke, Julia, Frison, Gilles, Hui, Renjie, van Der Rest, Guillaume   +3 more
core   +1 more source

Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus [PDF]

, 2018
Background: Systematic lupus erythematosus (SLE) is characterized with various complications which can cause serious organ damage in the human body. Despite the significant improvements in disease management of SLE patients, the non-invasive diagnosis ...
Burkly, L.C., Mischak, H., Mullen, W., Pejchinovski, M., Petri, M.A., Siwy, J., Wei, R.   +6 more
core   +1 more source

The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. [PDF]

, 1993
A common feature shared by myosin-binding proteins from a wide variety of species is the presence of a variable number of related internal motifs homologous to either the Ig C2 or the fibronectin (Fn) type III repeats.
Fischman, DA, Mikawa, T, Okagaki, T, Reinach, FC, Vaughan, KT, Weber, FE   +5 more
core  

UV-induced ligand exchange in MHC class I protein crystals [PDF]

, 2009
High-throughput structure determination of protein−ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy.
Adams P. D., Bakker A. H., Bjorkman P. J., Blundell T. L., Borbulevych O. Y., Bosques C. J., Bourgeois D., Bouvier M., CCP4 (Collaborative Computational Project) N., Dudley M. E., Emsley P., Evans P. R., Frickel E. M., Garcia K. C., Grotenbreg G. M., Grotenbreg G. M., Hosken N., Kontopidis G., Lewinsohn D. A., Ljunggren H. G., Madden D. R., Moffat K., Murshudov G. N., Newman J., Oseroff C., Rodenko B., Schlichting I., Schumacher T. N., Speiser D. E., Sylwester A. W., Toebes M., Vriend G., Yewdell J. W.   +32 more
core   +1 more source

Predicting Intensity Ranks of Peptide Fragment Ions [PDF]

Journal of Proteome Research, 2009
Accurate modeling of peptide fragmentation is necessary for the development of robust scoring functions for peptide-spectrum matches, which are the cornerstone of MS/MS-based identification algorithms. Unfortunately, peptide fragmentation is a complex process that can involve several competing chemical pathways, which makes it difficult to develop ...
openaire   +3 more sources

Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative [PDF]

, 2012
Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.Board of Regents, University of ...
Carney, Darrell H., Fossum, Theresa W., Olszewska-Pazdrak, Barbara   +2 more
core   +1 more source

Erratum to: Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia. [PDF]

Dokl Biochem Biophys, 2023
Severyukhina MS, Ismailova AM, Shaykhutdinova ER, Dyachenko IA, Egorova NS, Murashev AN, Tsetlin VI, Utkin YN.   +7 more
europepmc   +1 more source