Dynamical System Modeling to Simulate Donor T Cell Response to Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness in Clinical Outcomes Following Stem Cell Transplantation [PDF]
PLoS One. 2017 Dec 1;12(12):e0187771, 2016 Alloreactivity following stem cell transplantation (SCT) is difficult to predict in patients undergoing transplantation from HLA matched donors. In this study we performed whole exome sequencing of SCT donor-recipient pairs (DRP). This allowed determination of entire library of alloreactive peptide sequences which would bind HLA class I molecules in ...
arxiv +1 more source
Generating High-Accuracy Peptide-Binding Data in High Throughput with Yeast Surface Display and SORTCERY [PDF]
, 2018 Library methods are widely used to study protein-protein interactions, and high-throughput screening or selection followed by sequencing can identify a large number of peptide ligands for a protein target. In this chapter, we describe a procedure called "
Dutta, Sanjib +2 more
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Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop
Neural Regeneration Research, 2015 Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown.
Ling-ling Shen +11 more
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Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains [PDF]
, 2018 Alpha helices form a critical part of the binding interface for many protein-protein interactions, and chemically stabilized synthetic helical peptides can be effective inhibitors of such helix-mediated complexes.
Keating, Amy E. +3 more
core +1 more source
Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire [PDF]
, 1995 Making use of mice deficient for terminal deoxynucleotidyl transferase (TdT) expression and a random peptide library, we have examined the diversity and peptide specificity of the neonatal T cell repertoire specific for a single H-2Db-restricted peptide.
Bevan, Michael J., Gavin, Marc A.
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Pharmacological applications of natural peptide libraries [PDF]
BMC Pharmacology and Toxicology, 2012 BackgroundThe diversity in nature has long been and still is one of thebiggest resources of pharmaceutical lead compounds andmany natural products ofte n exhibit biological activityagainst unrelated biological targets, thus providing us withstarting points for drug development.
Carsten Gründemann +3 more
openaire +2 more sources
Molecules, 2014 The design, synthesis and screening of diversity-oriented peptide libraries using a “libraries from libraries” strategy for the development of inhibitors of α1-antitrypsin deficiency are described. The major buttress of the biochemical approach presented
Yi-Pin Chang, Yen-Ho Chu
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Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide [PDF]
, 2015 The NF-κB transcriptional response is tightly regulated by a number of processes including the phosphorylation, ubiquitination, and subsequent proteasomal degradation of NF-κB subunits.
Carmody, Ruaidhri J. +6 more
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Biomathematical Description of Synthetic Peptide Libraries
PLOS ONE, 2015 Libraries of randomised peptides displayed on phages or viral particles are essential tools in a wide spectrum of applications. However, there is only limited understanding of a library's fundamental dynamics and the influences of encoding schemes and sizes on their quality.
Sieber, Timo +3 more
openaire +6 more sources
Screening technology of cyclic peptide library based on gene encoding
Medicine in Drug Discovery, 2022 As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen +5 more
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