Results 71 to 80 of about 433,652 (251)

Biological conduits combining bone marrow mesenchymal stem cells and extracellular matrix to treat long-segment sciatic nerve defects

open access: yesNeural Regeneration Research, 2015
The transplantation of polylactic glycolic acid conduits combining bone marrow mesenchymal stem cells and extracellular matrix gel for the repair of sciatic nerve injury is effective in some respects, but few data comparing the biomechanical factors ...
Yang Wang   +4 more
doaj   +1 more source

Biomathematical Description of Synthetic Peptide Libraries

open access: yesPLOS ONE, 2015
Libraries of randomised peptides displayed on phages or viral particles are essential tools in a wide spectrum of applications. However, there is only limited understanding of a library's fundamental dynamics and the influences of encoding schemes and sizes on their quality.
Sieber, Timo   +3 more
openaire   +5 more sources

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

open access: yes, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D   +2 more
core   +1 more source

Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus

open access: yesNeural Regeneration Research, 2015
The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet.
Eun Joo Bae   +14 more
doaj   +1 more source

Man-Made Synthetic Receptors for Capture and Analysis of Ochratoxin A

open access: yesToxins, 2015
Contemporary analytical methods have the sensitivity required for Ochratoxin A detection and quantification, but direct application of these methods on real samples can be rarely performed because of matrix complexity.
Claudio Baggiani   +2 more
doaj   +1 more source

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

open access: yesNature Communications, 2021
Many interactions between viral and host proteins are mediated by short peptide motifs. Here, using a phage-based viral peptide library, the authors identify 269 peptide-based interactions for 18 coronaviruses, including an interaction between SARS-CoV-2
Thomas Kruse   +21 more
doaj   +1 more source

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. [PDF]

open access: yes, 2013
Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic ...
Eisenberg, David S   +6 more
core   +1 more source

Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

open access: yesNeural Regeneration Research, 2015
The morphological changes that occur in the taste buds after denervation are not well understood in rats, especially in the contralateral tongue epithelium.
Yi-ke Li   +4 more
doaj   +1 more source

A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

open access: yesCommunications Biology, 2023
Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.
Waka Sato   +15 more
doaj   +1 more source

N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]

open access: yes, 2017
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris   +8 more
core   +1 more source

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