Biosynthesis, chemical structure, and structure-activity relationship of orfamide lipopeptides produced by Pseudomonas protegens and related species [PDF]
, 2016 Orfamide type cyclic lipopeptides (CLPs) are biosurfactants produced by Pseudomonas and involved in lysis of oomycete zoospores, biocontrol of Rhizoctonia and insecticidal activity against aphids.
Geudens, Niels +6 more
core +3 more sources
Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase [PDF]
IUCrJ, 2019 Indanomycin is biosynthesized by a hybrid nonribosomal peptide synthase/polyketide synthase (NRPS/PKS) followed by a number of `tailoring' steps to form the two ring systems that are present in the mature product. It had previously been hypothesized that the indane ring of indanomycin was formed by the action of IdmH using a Diels–Alder reaction. Here,
Ieva Drulyte +6 more
openaire +7 more sources
Species-Specific Differences in the Susceptibility of Fungi to the Antifungal Protein AFP Depend on C-3 Saturation of Glycosylceramides [PDF]
, 2019 AFP is an antimicrobial peptide (AMP) produced by the filamentous fungus Aspergillus giganteus and is a very potent inhibitor of fungal growth that does not affect the viability of bacteria, plant, or mammalian cells.
Baumann, Birgit +8 more
core +1 more source
Mining microbial genomes for new natural products and biosynthetic pathways [PDF]
, 2008 Analyses of microbial genome sequences have revealed numerous examples of ‘cryptic’ or ‘orphan’ biosynthetic gene clusters, with the potential to direct the production of novel, structurally complex natural products.
Austin +67 more
core +2 more sources
Nonribosomal Peptide Synthesis in Animals: The Cyclodipeptide Synthase of Nematostella
Chemistry & Biology, 2011 Cyclodipeptide synthases (CDPSs) are small enzymes structurally related to class-I aminoacyl-tRNA synthetases (aaRSs). They divert aminoacylated tRNAs from their canonical role in ribosomal protein synthesis, for cyclodipeptide formation. All the CDPSs experimentally characterized to date are bacterial.
Seguin, Jérôme +8 more
openaire +3 more sources
Production of ent-kaurene from lignocellulosic hydrolysate in Rhodosporidium toruloides. [PDF]
, 2020 BACKGROUND:Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and co-utilize sugars and lignin ...
Burnum-Johnson, Kristin E +15 more
core +1 more source
Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]
, 2001 The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia +4 more
core +1 more source
The Fungal Cell Wall : Structure, Biosynthesis, and Function [PDF]
, 2017 N.G. is funded by the Wellcome Trust via a senior investigator award and a strategic award and by the MRC Centre for Medical Mycology. C.M. acknowledges the support of the Wellcome Trust and the MRC. N.G. and C.M.
Aimanianda +215 more
core +1 more source
Phylogenomic analyses of non-Dikarya fungi supports horizontal gene transfer driving diversification of secondary metabolism in the amphibian gastrointestinal symbiont, Basidiobolus [PDF]
, 2020 Research into secondary metabolism (SM) production by fungi has resulted in the discovery of diverse, biologically active compounds with significant medicinal applications. However, the fungi rich in SM production are taxonomically restricted to Dikarya,
Chang, Ying +9 more
core +1 more source
Pass-back chain extension expands multimodular assembly line biosynthesis. [PDF]
, 2020 Modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymatic assembly lines are large and dynamic protein machines that generally effect a linear sequence of catalytic cycles.
Huan, Tao +5 more
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