Results 21 to 30 of about 4,400,665 (341)

Greening Fmoc/tBu solid-phase peptide synthesis

, 2020
Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi, B. G. de la Torre, F. Albericio   +2 more
semanticscholar   +1 more source

Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]

, 2019
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan, Nuño, Manuel, Seeberger, Peter H., Sletten, Eric T.   +3 more
core   +2 more sources

Game Change from Reagent- to Substrate-Controlled Peptide Synthesis

, 2020
An account of the development of Lewis-acid-catalyzed methods for racemization-free peptide synthesis is presented.
Wataru Muramatsu, Tomohiro Hattori, Hisashi Yamamoto   +2 more
semanticscholar   +1 more source

Automated Peptide Synthesizers and Glycoprotein Synthesis

Frontiers in Chemistry, 2022
The development and application of commercially available automated peptide synthesizers has played an essential role in almost all areas of peptide and protein research.
Jiekang Tian, Yaohao Li, Bo Ma, Zhongping Tan, Shiying Shang   +4 more
doaj   +1 more source

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

Self-assembly of minimal peptoid sequences [PDF]

, 2020
Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding.
Castelletto, Valeria, Edkins, Robert M., Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Seitsonen, Jani, Tewari, Kunal M.   +8 more
core   +2 more sources

Inter-residue through-space scalar ¹⁹F–¹⁹F couplings between CH₂F groups in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of leucine by (2S,4S)-5-fluoroleucine (FLeu1), (2S,4R)-5-fluoroleucine (FLeu2), or 5,5′-difluoroleucine (diFLeu).
Y. J. Tan, E. H. Abdelkader, I. D. Herath, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production.

Journal of Organic Chemistry, 2019
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials, and >200 in preclinical development.
Albert Isidro-Llobet, Martin N. Kenworthy, Subha Mukherjee, M. Kopach, K. Wegner, F. Gallou, Austin G. Smith, F. Roschangar   +7 more
semanticscholar   +1 more source

Peptide-directed crystal growth modification in the formation of ZnO [PDF]

, 2015
Biomolecule-mediated synthesis is fascinating in terms of the level of control and the intricate hierarchical structures of the materials that can be produced.
Liang, M-K, Perry, CC, Roe, MJ, Sola-Rabada, A   +3 more
core   +1 more source