Results 21 to 30 of about 588,234 (285)

Automated Peptide Synthesizers and Glycoprotein Synthesis

Frontiers in Chemistry, 2022
The development and application of commercially available automated peptide synthesizers has played an essential role in almost all areas of peptide and protein research.
Jiekang Tian, Yaohao Li, Bo Ma, Zhongping Tan, Shiying Shang   +4 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source

Commercial manufacturing of current good manufacturing practice peptides spanning the gamut from neoantigen to commercial large-scale products

Medicine in Drug Discovery, 2021
Peptide therapeutics represents a significant and growing area for manufacturing companies utilizing both chemical and recombinant methods. Approvals for orally administered peptides such as Linzess® (linaclotide), Trulance® (plecanatide), and most ...
Michael W. Pennington, Brant Zell, Chris J. Bai   +2 more
doaj   +1 more source

A deeper mining on the protein composition of VA-MENGOC-BC®: An OMV-based vaccine against N. meningitidis serogroup B and C

Human Vaccines & Immunotherapeutics, 2017
The protein composition of an Outer Membrane Vesicle (OMV) preparation that constitutes the active pharmaceutical ingredient of VA-MENGOC-BC®, an effective vaccine against Neisseria meningitidis serogroups B, and C is presented.
Yordanka Masforrol, Jeovanis Gil, Darien García, Jesús Noda, Yassel Ramos, Lázaro Betancourt, Osmany Guirola, Sonia González, Boris Acevedo, Vladimir Besada, Osvaldo Reyes, Luis Javier González   +11 more
doaj   +1 more source

Realizing Serine/Threonine Ligation: Scope and Limitations and Mechanistic Implication Thereof

Frontiers in Chemistry, 2014
Serine/Threonine ligation (STL) has emerged as an alternative tool for protein chemical synthesis, bioconjugations as well as macrocyclization of peptides of various sizes. Owning to the high abundance of Ser/Thr residues in natural peptides and proteins,
Clarence T. T. Wong, Clarence T. T. Wong, Tianlu eLi, Tianlu eLi, Hiu Yung eLam, Hiu Yung eLam, Yinfeng eZhang, Yinfeng eZhang, Xuechen eLI, Xuechen eLI, Xuechen eLI   +10 more
doaj   +1 more source

γ effects identify preferentially populated rotamers of CH₂F groups: side-chain conformations of fluorinated valine analogues in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of valine by (2S,3S)-4-fluorovaline, (2S,3R)-4-fluorovaline or 4,4'-difluorovaline.
E. H. Abdelkader, N. F. Chilton, N. F. Chilton, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions

Molecules, 2021
Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described
Shinya Yano, Toshihiro Mori, Hideki Kubota   +2 more
doaj   +1 more source

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

Molecules, 2021
This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells.
Félix Gayraud, Merlin Klußmann, Ines Neundorf   +2 more
doaj   +1 more source

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

Beilstein Journal of Organic Chemistry, 2018
The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj   +1 more source

Exploiting Conserved Quorum Sensing Signals in Streptococcus mutans and Streptococcus pneumoniae

Microorganisms, 2022
Bacterial species of the Streptococcus genera are considered either commensal bacteria or potential pathogens, according to their metabolic evolution and production of quorum sensing (QS)-controlled virulence factors. S. mutans, in particular, has become
Giulia Bernabè, Anthony Pauletto, Annj Zamuner, Leonardo Cassari, Ignazio Castagliuolo, Paola Brun, Monica Dettin   +6 more
doaj   +1 more source