Results 31 to 40 of about 962,899 (337)

Self-assembly of minimal peptoid sequences [PDF]

, 2020
Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding.
Castelletto, Valeria, Edkins, Robert M., Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Seitsonen, Jani, Tewari, Kunal M.   +8 more
core   +2 more sources

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

Inter-residue through-space scalar ¹⁹F–¹⁹F couplings between CH₂F groups in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of leucine by (2S,4S)-5-fluoroleucine (FLeu1), (2S,4R)-5-fluoroleucine (FLeu2), or 5,5′-difluoroleucine (diFLeu).
Y. J. Tan, E. H. Abdelkader, I. D. Herath, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Automated Peptide Synthesizers and Glycoprotein Synthesis

Frontiers in Chemistry, 2022
The development and application of commercially available automated peptide synthesizers has played an essential role in almost all areas of peptide and protein research.
Jiekang Tian, Yaohao Li, Bo Ma, Zhongping Tan, Shiying Shang   +4 more
doaj   +1 more source

Cardiomyocyte-Targeting Peptide to Deliver Amiodarone

Pharmaceutics, 2023
Background: Amiodarone is underutilized due to significant off-target toxicities. We hypothesized that targeted delivery to the heart would lead to the lowering of the dose by utilizing a cardiomyocyte-targeting peptide (CTP), a cell-penetrating peptide ...
Maliha Zahid, Beth Weber, Ray Yurko, Kazi Islam, Vaishavi Agrawal, Jack Lopuszynski, Hisato Yagi, Guy Salama   +7 more
doaj   +1 more source

Peptide-directed crystal growth modification in the formation of ZnO [PDF]

, 2015
Biomolecule-mediated synthesis is fascinating in terms of the level of control and the intricate hierarchical structures of the materials that can be produced.
Liang, M-K, Perry, CC, Roe, MJ, Sola-Rabada, A   +3 more
core   +1 more source

Commercial manufacturing of current good manufacturing practice peptides spanning the gamut from neoantigen to commercial large-scale products

Medicine in Drug Discovery, 2021
Peptide therapeutics represents a significant and growing area for manufacturing companies utilizing both chemical and recombinant methods. Approvals for orally administered peptides such as Linzess® (linaclotide), Trulance® (plecanatide), and most ...
Michael W. Pennington, Brant Zell, Chris J. Bai   +2 more
doaj   +1 more source

Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides [PDF]

, 2018
A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.
Gannon, Susan, Hezwani, Mohammed, Liskamp, Rob M.J., Pirvan, Alin, Postma, Tobias, Riehle, Mathis, Silva Nigenda, Ezequiel, Smith, Carol-Anne   +7 more
core   +1 more source

Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds [PDF]

, 2016
Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin containing four disulfide bridges, is a high affinity blocker of the voltage-gated potassium channel Kv1.3, but also blocks Kv1.2.
Bartok, Adam, Fehér, Krisztina, Illyés, Tünde Z, Kövéer, Katalin E, Panyi, Gyorgy, Rákosi, Kinga, Szolomájer, János, Timári, István, Tóth, Gábor K, Varga, Zoltan   +9 more
core   +2 more sources

A New Peptide Synthesis [PDF]

Nature, 1949
Cook, Heilbron and Levy1 have recently prepared tetraglycylglycine and several di-peptides by reaction of 2-thio-5-thiazolones with amino-acid derivatives. During the past few years, much interest has also been shown in the polymerization potentialities of the N-carboxy anhydrides of α-amino-acids2–5.
openaire   +2 more sources