Results 41 to 50 of about 855,791 (338)

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis

Beilstein Journal of Organic Chemistry, 2018
The system of the hypervalent iodine(III) reagent FPID and (4-MeOC6H4)3P was successfully applied to solid-phase peptide synthesis and cyclic peptide synthesis.
Dan Liu, Ya-Li Guo, Jin Qu, Chi Zhang
doaj   +1 more source

Capra cartilage-derived peptide delivery via carbon nano-dots for cartilage regeneration

Frontiers in Bioengineering and Biotechnology, 2023
Targeted delivery of site-specific therapeutic agents is an effective strategy for osteoarthritis treatment. The lack of blood vessels in cartilage makes it difficult to deliver therapeutic agents like peptides to the defect area.
Priti Prasanna Maity, Kausik Kapat, Puja Poddar, Hema Bora, Chandan Kanta Das, Poushali Das, Sayan Ganguly, Narayan Chandra Das, Dibakar Dhara, Mahitosh Mandal, Amit Roy Chowdhury, Sumanta Mukherjee, Santanu Dhara   +12 more
doaj   +1 more source

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Beilstein Journal of Organic Chemistry, 2019
The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis.
David C. B. Siebert, Roman Sommer, Domen Pogorevc, Michael Hoffmann, Silke C. Wenzel, Rolf Müller, Alexander Titz   +6 more
doaj   +1 more source

Protective Effect of Peptides from Pinctada Martensii Meat on the H₂O₂-Induced Oxidative Injured HepG2 Cells

Antioxidants, 2023
Pinctada martensii is a major marine pearl cultured species in southern China, and its meat is rich in protein, which is an excellent material for the preparation of bioactive peptides.
Jie Zhou, Mengfen Wei, Lijun You
doaj   +1 more source

Membrane-Active Peptides and Their Potential Biomedical Application

Pharmaceutics, 2023
Membrane-active peptides (MAPs) possess unique properties that make them valuable tools for studying membrane structure and function and promising candidates for therapeutic applications.
Andreea Gostaviceanu, Simona Gavrilaş, Lucian Copolovici, Dana Maria Copolovici   +3 more
doaj   +1 more source

A New Peptide Synthesis [PDF]

Nature, 1949
Cook, Heilbron and Levy1 have recently prepared tetraglycylglycine and several di-peptides by reaction of 2-thio-5-thiazolones with amino-acid derivatives. During the past few years, much interest has also been shown in the polymerization potentialities of the N-carboxy anhydrides of α-amino-acids2–5.
openaire   +3 more sources

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Pharmaceutics, 2022
Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage.
Yongsheng Liu, Rezan Güler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J. Meuleman, Anna Koijen, Leendert J. van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y. Frejd   +13 more
doaj   +1 more source

Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. [PDF]

, 2014
Multiple sclerosis (MS) is characterized by central nervous system (CNS) inflammation, demyelination, and axonal degeneration. CXCL10 (IP-10), a chemokine for CXCR3+ T cells, is known to regulate T cell differentiation and migration in the periphery, but
Bannerman, Peter, Burns, Travis, Guo, Fuzheng, Ko, David, Lee, Eunyoung, Ma, Joyce H, Miers, Laird, Mills Ko, Emily, Pleasure, David, Sohn, Jiho, Soulika, Athena M   +10 more
core   +3 more sources

Preparation, Radiolabeling with ⁶⁸Ga/¹⁷⁷Lu and Preclinical Evaluation of Novel Angiotensin Peptide Analog: A New Class of Peptides for Breast Cancer Targeting

Pharmaceuticals, 2023
Aim: Angiotensin II (AngII) is known to play a significant part in the development of breast cancer by triggering cell propagation of breast cancer, tumor angiogenesis, and regulating tumor invasion and cell migration. AngII arbitrates its action via two
Subhani M. Okarvi
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source