Results 41 to 50 of about 4,400,665 (341)

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 [PDF]

, 2006
Synthesis of the tripeptide Z-Phe-Arg-SerNH2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica), using Z-Phe-Arg-OMe as acyl acceptor and SerNH2 as nucleophile in 0.1 M ammonium acetate pH 9.0–12.5%
Ciarán Ó'Fágáin, Collins, Dalton, Deborah M. Ruth, Dowd, Dowd, Fujishima, Gillian McMahon, Haensler, Jakubke, Lozano, Mort, Ménard, Sewald, Stehle, Turk, Zhou   +16 more
core   +1 more source

Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis

Pharmaceutics, 2022
Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage.
Yongsheng Liu, Rezan Güler, Yunqi Liao, Anzhelika Vorobyeva, Olof Widmark, Theodorus J. Meuleman, Anna Koijen, Leendert J. van den Bos, Robert Naasz, Vitalina Bodenko, Anna Orlova, Caroline Ekblad, Vladimir Tolmachev, Fredrik Y. Frejd   +13 more
doaj   +1 more source

Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication.

Organic Letters, 2019
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically ...
F. Merlino, Stefano Tomassi, A. M. Yousif, A. Messere, L. Marinelli, P. Grieco, E. Novellino, S. Cosconati, Salvatore Di Maro   +8 more
semanticscholar   +1 more source

Synthesis of Peptide Bioconjugates [PDF]

ChemInform, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
openaire   +4 more sources

Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides

ACS Sustainable Chemistry and Engineering, 2019
To replace dimethylformamide (DMF) in fluorenylmethoxycarbonyl (Fmoc) solid-phase peptide synthesis, we explored the application of mixtures of green solvents (green solvents mixtures for solid-phase peptide synthesis (GM-SPPS)) as combinations of Cyrene
L. Ferrazzano, Dario Corbisiero, Giulia Martelli, A. Tolomelli, Angelo Viola, Antonio Ricci, W. Cabri   +6 more
semanticscholar   +1 more source

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +2 more sources

Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis

Journal of Organic Chemistry
Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many attractive targets are poorly tractable by small molecules, generating a need for new therapeutic modalities.
Ivy Kekessie, Katarzyna Wegner, Isamir Martínez, M. Kopach, Timothy White, Janine K. Tom, Martin N. Kenworthy, Fabrice Gallou, John Lopez, Stefan G. Koenig, Philippa R Payne, Stefan Eissler, Balasubramanian Arumugam, Changfeng Li, Subha Mukherjee, Albert Isidro-Llobet, O. Ludemann‐Hombourger, Paul F. Richardson, Jörg Kittelmann, D. Sejer Pedersen, Leendert J van den Bos   +20 more
semanticscholar   +1 more source

Catalytic Dehydrative Peptide Synthesis with gem-Diboronic Acids

ACS Catalysis, 2019
Alkane-gem-diboronic acids have emerged as versatile organoboron catalysts for dehydrative amidation of α-amino acids. A phenol-substituted multiboron catalyst with a B–C–B structure outperformed simple arylboronic acids in the condensation of α-amino ...
Kenichi Michigami, Tatsuhiko Sakaguchi, Y. Takemoto   +2 more
semanticscholar   +1 more source

Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries. [PDF]

, 2008
Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has
Greaves, John, Juskowiak, Gary L, McGee, Christopher J, Van Vranken, David L   +3 more
core   +2 more sources