A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens [PDF]
Science, 2016 The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient to protect Caenorhabditis elegans
Shai Shaham, , Virginia A Pedicord
exaly +5 more sources
Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses. [PDF]
PLoS Pathogens, 2022 Synthesis of the capsular polysaccharide, a major virulence factor for many pathogenic bacteria, is required for bacterial survival within the infected host.
Joana Figueiredo +10 more
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Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in
mBio, 2019 Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed.
Britta E. Rued +11 more
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A new regulator of the Staphylococcus aureus peptidoglycan hydrolase Sle1. [PDF]
PLoS GeneticsRegulation of peptidoglycan hydrolases is crucial for bacterial cell integrity, growth and division. In the bacterial pathogen Staphylococcus aureus, the amidase Sle1 is a key autolysin required for septum splitting and daughter cell separation.
Helena Veiga +3 more
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Inhibiting Peptidoglycan Hydrolase Alleviates MRSA Pneumonia Through Autolysin-Mediated MDP-NOD2 Pathway [PDF]
Infection and Drug ResistanceYang Yang,1,2 Zongze Yao,1 Jiazhen Zhang,1 Wei Shao,3 Bo Li,2 Huihui Wu,2 Wenjian Tang,3 Jing Zhang2 1School of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 2Anhui Province Key Laboratory of Occupational ...
Yang Y +7 more
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Identification of the chain-dispersing peptidoglycan hydrolase LytB of Streptococcus gordonii. [PDF]
PLoS ONE, 2017 Bacterial cell division ends with the separation of the daughter cells, a process that requires peptidoglycan hydrolases (PGHs). Bacteria lacking cell separating PGHs are impaired in cell separation with the formation of long chains or clusters.
Riccardo Arrigucci, Gianni Pozzi
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Enterococcus faecium sagA mutants have cell envelope defects influencing antibiotic resistance and bacteriophage susceptibility [PDF]
Journal of BacteriologyEnterococcus faecium is a gram-positive bacterium that is resident to the intestines of animals including humans. E. faecium is also an opportunistic pathogen that causes multidrug-resistant (MDR) infections. Bacteriophages (phages) have been proposed as
Garima Arya +5 more
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Genetic Dissection of the Type VI Secretion System in
mBio, 2016 The type VI secretion system (T6SS) is a widespread secretory apparatus produced by Gram-negative bacteria that has emerged as a potent mediator of antibacterial activity during interbacterial interactions.
Brent S. Weber +8 more
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eLife, 2022 The helical shape of Helicobacter pylori cells promotes robust stomach colonization; however, how the helical shape of H. pylori cells is determined is unresolved.
Sophie R Sichel +2 more
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mBio, 2023 Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang +2 more
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