Results 121 to 130 of about 26,717 (273)

Multivalency Increases the Binding Strength of RGD Peptidomimetic‐Paclitaxel Conjugates to Integrin αVβ3

Chemistry, 2017
This work reports the synthesis of three multimeric RGD peptidomimetic‐paclitaxel conjugates featuring a number of αVβ3 integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin αVβ3 ligand cyclo[DKP‐RGD]‐CH2NH2
André Raposo Moreira Dias, A. Pina, Alberto Dal Corso, D. Arosio, L. Belvisi, L. Pignataro, M. Caruso, C. Gennari   +7 more
semanticscholar   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Stereochemical Behavior of Pyrrolo-Pyrazole Peptidomimetics Promoting Phase-Selective Supramolecular Organogels

Gels
Supramolecular gels were developed by taking advantage of an assembly of small dipeptides containing pyrrolo-pyrazole scaffolds. The dipeptides were prepared through a robust and ecofriendly synthetic approach from the commercially available starting ...
Enrica Chiesa, Francesco Anastasi, Francesca Clerici, Edoardo Mario Lumina, Ida Genta, Sara Pellegrino, Maria Luisa Gelmi   +6 more
doaj   +1 more source

Structure and substrate recognition of the Bottromycin maturation enzyme BotP [PDF]

, 2016
JK would like to thank the University of St Andrews, which is supported by a Wellcome Trust Capital Award (086036) and the Deutsche Forschungsgemeinschaft for an Emmy Noether fellowship (KO4116/3-1).
Adam, Sebastian, Huo, Liujie, Koehnke, Jesko, Mann, Greg, Müller, Rolf, Nardone, Brunello, Vendome, Jeremie, Westwood, Nicholas James   +7 more
core   +1 more source

Pasireotide for the Medical Management of Feline Hypersomatotropism [PDF]

, 2015
BACKGROUND: Feline hypersomatotropism (HST) is a cause of diabetes mellitus in cats. Pasireotide is a novel multireceptor ligand somatostatin analog that improves biochemical control of humans with HST.
Abraham, Adams, Alt, Appleton, Bhayana, Bruns, Castillo, Church, Colao, Colao, Cuevas-Ramos, Fedele, Fernandez-Rodriguez, Fougner, Golor, Henry, Hofland, Juul, Katznelson, Kvols, Lamb, Lamberts, Maxwell, Meij, Miller, Murray, Myers, Niessen, Niessen, Niessen, Niessen, Petrus, Polska, Rand, Ray, Schmid, Schmid, Sheppard, Slingerland, Sohmiya, Starkey, Stolk, Taboada, Wajchenberg, Zatelli, Zou   +45 more
core   +2 more sources

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

Chemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner, Saad Shaaban, Nuno Maulide   +2 more
wiley   +1 more source

Heterocycles in Peptidomimetics and Pseudopeptides: Design and Synthesis

Pharmaceuticals, 2012
This minireview provides a brief outline of the peculiar aspects of the preparation of peptidomimetic and pseudopeptidic structures containing heterocycles. In particular novel tricyclic structures are investigated as potential drugs.
Ambra Guarnaccio, Maria Funicello, Lucia Chiummiento, Iole Cerminara, Paolo Lupattelli   +4 more
doaj   +1 more source

Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus. [PDF]

, 2014
Despite showing promise in preclinical models, anti-Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively inducing cellular immunity have not ...
Chan, K., Collin, N., Foster, T.J., Fox, J., Geoghegan, J.A., Heuking, S., Lavelle, E.C., McLoughlin, R.M., McNeela, E.A., Misstear, K., Murphy, A.G., O'Keeffe, K.M.   +11 more
core   +2 more sources

Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8

SLAS discovery : advancing life sciences R & D, 2018
The identification of protein ligands from a DNA-encoded library is commonly conducted by an affinity selection assay. These assays are often not validated for robustness, raising questions about selections that fail to identify ligands and the utility ...
Kyle E Denton, Sijie Wang, Michael C. Gignac, Natalia Milosevich, F. Hof, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
semanticscholar   +1 more source

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations

Molecules, 2016
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou, William L. Scott, Martin J. O’Donnell   +2 more
doaj   +1 more source