Results 1 to 10 of about 5,492 (203)
Synthesis of Boron-Containing Primary Amines [PDF]
Molecules, 2013 In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung +4 more
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A novel bioactive peptide-peptoid hybrid of alpha-calcitonin gene-related peptide protects against pressure-overload induced heart failure [PDF]
Frontiers in PharmacologyBackgroundAlpha-calcitonin gene-related peptide (α-CGRP) is a cardioprotective neuropeptide. However, due to low bioavailability, its use as a therapeutic agent is limited.
Ambrish Kumar +4 more
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Functionalized Surface Coatings for Rigid Contact Lenses [PDF]
Journal of Functional BiomaterialsThis research evolves into a comparative study of three different phenolic composites as coatings for rigid contact lenses, with a particular emphasis on enhancing their antifouling properties and hydrophobicity.
Roeya Refaei +8 more
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Topology-Dependent Antifreeze Properties of Biomimetic Linear and Star-Shaped Peptoids [PDF]
BiomimeticsDeveloping safe and efficient cryoprotectants is critical for effective cryopreservation in biomedical applications. Inspired by natural antifreeze proteins (AFPs), a series of linear and star-shaped peptoids featuring isopropanol side chains to mimic ...
Lei Feng +7 more
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Cis-trans isomerization of peptoid residues in the collagen triple-helix
Nature Communications, 2023 Cis-peptide bonds are rare in proteins, and building blocks less favorable to the trans-conformer have been considered destabilizing. Although proline tolerates the cis-conformer modestly among all amino acids, for collagen, the most prevalent proline ...
Rongmao Qiu +7 more
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Applying a Hydrophilic Modified Hollow Fiber Membrane to Reduce Fouling in Artificial Lungs
Separations, 2021 Membranes for use in high gas exchange lung applications are riddled with fouling. The goal of this research is to create a membrane that can function in an artificial lung until the actual lung becomes available for the patient.
Nawaf Alshammari +2 more
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Peptoid microsphere coatings to improve performance in sandwich ELISA microarrays
Sensing and Bio-Sensing Research, 2021 Enzyme-linked immunosorbent assay (ELISA) microarray performance is limited by low assay sensitivity and dynamic range. Increasing the surface area for reagent binding can help to improve performance, but standard techniques such as roughening the ...
Jesse L. Roberts +2 more
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Sequence Changes Modulate Peptoid Self-Association in Water
Frontiers in Chemistry, 2020 Peptoids, N-substituted glycine oligomers, are a class of diverse and sequence-specific peptidomimetics with wide-ranging applications. Advancing the functional repertoire of peptoids to emulate native peptide and protein functions requires engineering ...
Amelia A. Fuller +8 more
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Beilstein Journal of Organic Chemistry, 2022 The synthesis and conformational analysis of the first series of peptoid oligomers composed of consecutive N-(alkylamino)glycine units is investigated. We demonstrate that N-(methylamino)glycine homooligomers can be readily synthesized in solution using ...
Maxime Pypec +3 more
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Cyclic Peptoid-Peptide Hybrids as Versatile Molecular Transporters
Frontiers in Chemistry, 2021 Addressing intracellular targets is a challenging task that requires potent molecular transporters capable to deliver various cargos. Herein, we report the synthesis of hydrophobic macrocycles composed of both amino acids and peptoid monomers. The cyclic
Claudine Nicole Herlan +6 more
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