Results 11 to 20 of about 5,492 (203)

Self-assembly of minimal peptoid sequences [PDF]

ACS Macro Letters, 2020
Peptoids are biofunctional N-substituted glycine peptidomimics. Their self-assembly is of fundamental interest because they demonstrate alternatives to conventional peptide structures based on backbone chirality and beta-sheet hydrogen bonding.
Castelletto, Valeria, Edkins, Robert M., Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Seitsonen, Jani, Tewari, Kunal M.   +8 more
core   +9 more sources

Water-Soluble Peptoids with Two Different Binding Sites for Strong ATP Chelation. [PDF]

Chemistry
ATP is key for activating enzymes associated with cancer. A potential therapeutic approach is strong binding of ATP, making it unavailable to enzymes. The water‐soluble peptoid P1‐TB incorporates two synergistic binding sites for ATP: terpyridine‐Zn²⁺ and 4‐CPBA that bind ATP's phosphate and diol groups, respectively, and exhibits an exceptional Kᴅ‐ATP
Vorobyov N, Maayan G.
europepmc   +2 more sources

Cationic Peptoids for Systemic In Vivo Cartilage-Targeting. [PDF]

Adv Sci (Weinh)
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Zhang C, Qiu R, Huang Y, Liu Y, Huang K, Zhao S, Li Y.   +6 more
europepmc   +2 more sources

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Pharmaceuticals, 2023
Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens,
Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato, Irene Izzo, Francesco De Riccardis, Marialuisa Siepi, Rosanna Culurciello, Nunzia D’Urzo, Emiliano Chiarot, Antonina Torre, Elio Pizzo, Marcello Merola, Eugenio Notomista   +13 more
doaj   +1 more source

Peptides blocking ApoE pathological function safely reduce pathology in TgSwDI/apoE2, 3 and 4 AD mice [PDF]

Alzheimers Dement
Abstract Background We previously demonstrated that a peptoid (LPFFA) prevents Aβ binding to human apoE producing cognitive rescue and reduced Aβ pathology on AD mouse models. We have now developed specific peptides that disrupt α‐helices essential for apoE conformation and pathological function; and tested, in cerebral amyloid angiopathy (CAA) TgSwDI ...
Goni F, Wang D, Suazo J, Lin J, Okeagu J, Gamallo‐Lana B, Mar A, Wisniewski T.   +7 more
europepmc   +2 more sources

Chain-end modifications and sequence arrangements of antimicrobial peptoids for mediating activity and nano-assembly [PDF]

, 2020
Poly(N-substituted glycine) “peptoids” are an interesting class of peptidomimics that can resist proteolysis and mimic naturally found antimicrobial peptides (AMPs), which exhibit wide spectrum activity against bacteria.
Castelletto, Valeria, Hamley, Ian W., Hasan, Abshar, Lau, King Hang Aaron, Pandey, Lalit M., Ruokolainen, Janne, Saxena, Varun, Sefcik, Jan, Seitsonen, Jani, Zimbitas, Georgina   +9 more
core   +2 more sources

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Frontiers in Chemistry, 2020
Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler   +5 more
doaj   +1 more source

Molecular modeling studies of peptoid polymers

AIMS Materials Science, 2017
Peptoids, or poly-N-substituted glycines, are synthetic polymers composed of a protein backbone with side chains attached to the nitrogen atoms rather than the α-carbons. Peptoids are biomimetic and protease resistant and have been explored for a variety
Laura J. Weiser, Erik E. Santiso
doaj   +1 more source

Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets. [PDF]

, 2019
The ability of antibodies to bind a wide variety of analytes with high specificity and high affinity makes them ideal candidates for therapeutic and diagnostic applications. However, the poor stability and high production cost of antibodies have prompted
Abate, Adam R, Cardiel, Joshua, Chen, Chun-Long, Chen, Yulin, Connolly, Michael D, Dehigaspitiya, Dilani C, Grzincic, Elissa M, Jian, Tengyue, Karbaschi, Mohsen, Kim, Jae Hong, Kim, Samuel C, Kirshenbaum, Kent, Kline, Mark A, Liu, Jianfang, Murray, Daniel J, Ren, Gang, Tresca, Blakely W, Udumula, Venkatareddy, Yun, Lisa, Zuckermann, Ronald N   +19 more
core   +1 more source

Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]

, 2013
The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
A Ghosh, AC Pawlyk, AM Quinn, CW Diehnelt, D Hessels, D Shen, DB Sodee, Duanwen Shen, E Basch, F Yi, Fei Xie, GA Lazar, H Liu, H Liu, H-S Lim, HD Agnew, IM Thompson, Irina U. Agoulnik, J Yu, JA Arter, JR Mesters, JR Newton, KA Noren, MI Davis, MI Milowsky, MJ Morris, MJ Morris, MJ Roobol, NH Bander, RK Nam, S Aggarwal, S Kim, S Minner, SE Lupold, SM Hillier, SR Banerjee, SR Banerjee, SR Banerjee, SR Banerjee, SS Chang, SZ Li, TJ Wigle, V Humblet, W. Barry Edwards, Y Chen, Y Chen, Y Chen, Z Xiao, ZY Zhu   +48 more
core   +16 more sources