Results 31 to 40 of about 5,492 (203)
Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations [PDF]
, 2018 Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility.
Barz, Matthias +4 more
core +3 more sources
Frontiers in Microbiology, 2020 Tuberculosis (TB) results in both morbidity and mortality on a global scale. With drug resistance on the increase, there is an urgent need to develop novel anti-mycobacterials.
Jasmeet Singh Khara +8 more
doaj +1 more source
Development of Peptoid-Based Ligands for the Removal of Cadmium from Biological Media. [PDF]
, 2015 Cadmium poisoning poses a serious health concern due to cadmiums increasing industrial use, yet there is currently no recommended treatment. The selective coordination of cadmium in a biological environment-i.e.
Francis, Matthew +2 more
core +2 more sources
Organic Letters, 2008 The first synthesis of functionalized -peptoid macrocycles is reported. X-ray crystallographic structure of tetramer 9 reveals a C2-symmetrical derivative with unexpected all-cis-amide bonds and spatial disposition of the appendages toward the two opposite faces of the ring. Quantum calculations suggest that 9 is locked in this layout.
Roy, Olivier +4 more
openaire +2 more sources
A peptoid interleukin‐15 receptor antagonist suppresses inflammation and arthritis in mice
Clinical & Translational Immunology, 2022 Objective To discover a novel peptoid antagonist that targets the interleukin‐15 (IL‐15) receptor and to evaluate its therapeutic efficacy in the treatment of inflammation and arthritis. Methods A new compound (IFRA3, interleukin‐15 receptor antagonist 3)
Kwang Bog Cho +11 more
doaj +1 more source
Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds [PDF]
, 2015 β-Peptoids are peptidomimetics based on N-alkylated β-aminopropionic acid residues (or N-alkyl-β-alanines). This type of peptide mimic has previously been incorporated in biologically active ligands and has been hypothesized to be able to exhibit ...
Fristrup, Peter +3 more
core +1 more source
Molecules, 2018 Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the ...
Ines Greco +8 more
doaj +1 more source
Molecules, 2007 Two new groups of cholane-peptoid hybrid macrocycles were produced by implementing novel combinations of the MiB methodology. Steroid-based hybrid macrolactams including heterocycle and aryl moieties were obtained by utilizing cholanic dicarboxylic acids
Ludger A. Wessjohann, Daniel G. Rivera
doaj +1 more source
Review: Structure-Activity Relationship of Antimicrobial Peptoids
Pharmaceutics, 2023 Due to their broad-spectrum activity against Gram-negative and Gram-positive bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs have emerged as prospective therapies for treating illnesses brought on by multi-drug resistant ...
Priscilla L. Nyembe +2 more
doaj +1 more source
Membrane‐acting biomimetic peptoids against visceral leishmaniasis
FEBS Open Bio, 2023 Visceral leishmaniasis (VL) is among the most neglected tropical diseases in the world. Drug cell permeability is essential for killing the intracellular residing parasites responsible for VL, making cell‐permeating peptides a logical choice to address ...
Vivek Kumar +8 more
doaj +1 more source