Results 51 to 60 of about 5,492 (203)
Molecules, 2019 Methicillin-resistant Staphylococcus pseudintermedius (MRSP) constitutes an emerging health problem for companion animals in veterinary medicine. Therefore, discovery of novel antimicrobial agents for treatment of Staphylococcus-associated canine ...
Ines Greco +8 more
doaj +1 more source
Characterization of Novel Antimicrobial Peptoids [PDF]
Antimicrobial Agents and Chemotherapy, 1999 ABSTRACT Peptoids differ from peptides in that peptoids are composed of N-substituted rather than alpha-carbon-substituted glycine units. In this paper we report the in vitro and in vivo antibacterial activities of several antibacterial peptoids discovered by screening combinatorial chemistry libraries for bacterial growth ...
B, Goodson +12 more
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2012 Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six
Ricardo A. W. Neves Filho +3 more
doaj +1 more source
Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation [PDF]
, 2014 Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an
Elduque Busquets, Xavier +2 more
core +2 more sources
Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics
Advanced Healthcare Materials, EarlyView.A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins +3 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.Isotactic poly(cyclohexene carbonate) crystalizes both as enantiopure polymer and upon stereocomplexation of the two opposite enantiomers. Both structures are characterized by multiple H‐‐‐O═C tight attractive interactions, whereas in the stereocomplex a tight interdigitation of the two enantiomeric chains occurs due to additional intimate dipole ...
Massimo Christian D'Alterio +5 more
wiley +2 more sources
Advanced Science, 2023 Antimicrobial peptides (AMPs) are promising therapeutics in the fight against multidrug‐resistant bacteria. As a mimic of AMPs, peptoids with N‐substituted glycine backbone have been utilized for antimicrobials with resistance against proteolytic ...
Minsang Kim +12 more
doaj +1 more source
Targeted Drug Delivery using Peptoid Based Nanospheres [PDF]
, 2016 While medicine has improved greatly in the last couple of decades, there are negative side effects that accompany many drugs. Undesirable side effects could be greatly reduced if non-systemic drug delivery systems were used because the medicine would ...
Smith, Kaylee J
core +2 more sources
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core
Linear peptidomimetics as potent antagonists of Staphylococcus aureus agr quorum sensing [PDF]
, 2018 Staphylococcus aureus is an important pathogen causing infections in humans and animals. Increasing problems with antimicrobial resistance has prompted the development of alternative treatment strategies, including antivirulence approaches targeting ...
Baldry, Mara +8 more
core +2 more sources