Results 61 to 70 of about 5,492 (203)
Advanced Science, EarlyView.A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding +5 more
wiley +1 more source
Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities
Nature Communications, 2022 Peroxidase mimics are currently being investigated as catalysts for lignin depolymerisation. In this article, the authors investigate a class of self-assembled and highly stable peptoid/hemin nanomaterials as peroxidase mimics that are highly stable and ...
Tengyue Jian +7 more
doaj +1 more source
Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview
Chemistry – A European Journal, EarlyView.The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati +4 more
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2019 Bioactive compounds, such as antimicrobial peptides (AMPs), have increasingly been used recently to counteract the rapidly increasing incidence of bacterial resistance to usual antibiotics and chemotherapeutics. In humans, endogenous AMPs are part of the
Meri Amerikova +4 more
doaj +1 more source
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids [PDF]
, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Brun Cubero, Omar +3 more
core +2 more sources
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang +7 more
wiley +1 more source
Peptoid special delivery [PDF]
Science-Business eXchange, 2008 Scientists at the University of Karlsruhe have designed peptoids that deliver therapeutics to intracellular targets without any toxic effects in vitro. The technique could produce carriers that deliver drugs exclusively to specific intracellular locations—if peptoids show as much promise in vivo.
openaire +1 more source
Synthesis and Characterization of Glyco‐Decorated Silsesquioxane‐Metallosalen Complexes
ChemistrySelect, Volume 11, Issue 5, 5 February 2026.Glyco‐decorated COSS‐metallosalen complexes were synthesized and characterized. Their metal ion‐dependent D4h or S4 geometry was experimentally verified by single‐crystal X‐ray diffraction using model compounds with the same tetranuclear core. Ribonuclease activity of these complexes was studied, but it remained modest compared to other metal ion‐based
Hanni Haapsaari +4 more
wiley +1 more source
Cross Metathesis Assisted Solid-Phase Synthesis of Glycopeptoids [PDF]
, 2012 A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good ...
Grubbs, Robert H. +3 more
core +1 more source
β-Peptoid Foldamers at Last [PDF]
Accounts of Chemical Research, 2015 For a long time, peptides were considered unsuitable for drug development due to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However, this paradigm has changed significantly in the past decade with the approval of numerous antibodies and proteins as drugs.
Laursen, Jonas S +2 more
openaire +3 more sources