Results 71 to 80 of about 5,492 (203)
Liquid–Liquid Phase Separation in Major Hallmarks of Cancer
Cell Proliferation, Volume 59, Issue 2, February 2026.Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie +10 more
wiley +1 more source
In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents. [PDF]
PLoS ONE, 2016 Bacterial resistance to conventional antibiotics is a global threat that has spurred the development of antimicrobial peptides (AMPs) and their mimetics as novel anti-infective agents.
Ann M Czyzewski +7 more
doaj +1 more source
Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids
Molecules, 2021 Outstanding affinity and specificity are the main characteristics of peptides, rendering them interesting compounds for basic and medicinal research. However, their biological applicability is limited due to fast proteolytic degradation.
Claudine Nicole Herlan +7 more
doaj +1 more source
Design and Synthesis of a Novel N-(1H-tetrazol-5-yl)methyl Cyclic Peptoid Using Nosyl-protected N-(1-trityl-1H-tetrazol-5-yl)methyl Substituted Glycine [PDF]
, 2017 : A solid phase synthesis of a cyclic peptoid bearing (1H-tetrazol-5-yl)methyl as N-substituent has been developed employing the monomer approach.
Krishnamurthy, M. +4 more
core +1 more source
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
Advanced Materials, Volume 38, Issue 4, 16 January 2026.Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon +5 more
wiley +1 more source
A Peptoid Ribbon Secondary Structure [PDF]
Angewandte Chemie International Edition, 2013 foldamers that have been shown to possess numerous biological functions and could find use in a range of fundamental and applied contexts as bio-inspired materials. Peptoids are highly attractive scaffolds for such purposes, as their non-native backbones are resistant to proteolytic degradation and their straightforward, modular synthesis enables the ...
J Aaron, Crapster +2 more
openaire +2 more sources
Aromatic Amide Foldamers Show Conformation‐Dependent Electronic Properties
ChemPhysChem, Volume 26, Issue 24, December 16, 2025.Aromatic foldamers with a trans configuration show enhanced conductance compared to shorter foldamers with a cis configuration due to efficient through‐bond electron tunneling. Electron transport in organic molecules and biomolecules is governed by electronic structure and molecular conformations.
Rajarshi Samajdar +10 more
wiley +1 more source
A readily applicable strategy to convert peptides to peptoid-based therapeutics. [PDF]
PLoS ONE, 2013 Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches.
Minyoung Park +3 more
doaj +1 more source
Non-natural protein mimetics for the treatment of Alzheimer\u27s disease [PDF]
, 2011 Alzheimer\u27s disease (AD) is a slow degenerative disease that causes memory loss and eventually leads to death. AD is caused by the aggregation of the amyloid-beta protein, found on the outside of brain cells; once the amyloid-beta protein begins to ...
Brown, Jasmine +4 more
core +1 more source
Scientific Reports, 2017 Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late onset Alzheimer’s disease (AD). Studies have shown that apoE, apoE4 in particular, binds to amyloid-β (Aβ) peptides at residues 12-28 of ...
Shan Liu +12 more
doaj +1 more source