Results 81 to 90 of about 5,492 (203)

Protein Isolation Using Peptoid Based Affinity Chromatography [PDF]

, 2013
Protein purification is essential for advancements in biotechnology. There are several different methods employed in purifying a particular protein from a complex sample such as a cell lysate.
Dunn, Megan
core   +1 more source

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Chronic Diseases and Translational Medicine, Volume 11, Issue 4, Page 269-278, December 2025.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li, Yuky Lam, Aaron Muth, Zhe‐Sheng Chen, Shanzhi Wang   +4 more
wiley   +1 more source

Characterization of an Affitoid Variable Region to be used for MDM-2 Detection in ELISA Microarray [PDF]

, 2013
Sandwich enzyme-linked immunosorbent assay (ELISA) microarray using peptoid-based affinity reagents, referred to as affitoids, is potentially a very powerful tool for the early detection of cancer and other complex diseases. Current detection methods for
Reinhard, Graham
core   +1 more source

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein [PDF]

, 2014
Pharmacological chaperones are small molecules that bind to proteins and stabilize them against thermal denaturation or proteolytic degradation, as well as assist or prevent certain protein-protein assemblies. These activities are being exploited for the
Burlak, Christopher, Hoang, Quyen, Im, Wonpil, Le, Ji Hoon, Lim, Hyun-Suk, Oh, Misook, Sirl Lee, Woo, Sun Lee, Hui, Wang, Wei   +8 more
core   +1 more source

Electroactive Proteinoid–Quantum Dot Systems

Small Science, Volume 5, Issue 12, December 2025.
Proteinoid‐quantum dot conjugates form toroidal nanostructures (145.2 nm outer diameter, 102.3 nm cavity) via glutamic acid‐phenylalanine‐aspartic acid‐cysteine cross‐linking with sulfo‐SMCC (sulfosuccinimidyl 4‐(N‐maleimidomethyl)cyclohexane‐1‐carboxylate).
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Formation of Molecularly Imprinted Polymer Matrices using [PDF]

, 2012
This study serves as a proof of concept that a poly(acrylonitrile-co-acrylic acid) may be used to form an chiral selective polymer membrane for discrimination of L-tryptophan from racemic tryptophan.
Erwin, William
core   +1 more source

Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study [PDF]

, 2016
We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have ...
A. A. Edwards, A.-S. Biesse-Martin, Armand, Arnaud-Neu, B. D. Alexander, B. V. Nielsen, Baskin, Baskin, Baskin, Bosque-Sendra, C. Taillefumier, Caumes, Conti, Culf, Culf, D. Mistry, Daily, De Cola, De Cola, De Santis, De Santis, Della Sala, Devarajan, Diamond, Dudek, Durán Merás, E. De Santis, Eberspaecher, G. Siligardi, Gorske, Goutelle, Han, Hinaje, Hioki, Hjelmgaard, Izzo, Javorfi, Kalugin, Kelly, Kirshenbaum, Knight, Knight, L. Waters, Lee, Maayan, Maayan, Maharani, Maulucci, Mishustin, Ovchinnikov, Pigot, R. Hussain, Roy, S. Faure, S. J. Holder, Schettini, Shannon, Shin, Siligardi, Siligardi, Stewart, Sui, Wu, Wu, Yoe, Yoo, Zabrodski, Zeng, Zsila   +68 more
core   +2 more sources

Antiviral Effect of Antimicrobial Peptoid TM9 and Murine Model of Respiratory Coronavirus Infection

Pharmaceutics
New antiviral agents are essential to improving treatment and control of SARS-CoV-2 infections that can lead to the disease COVID-19. Antimicrobial peptoids are sequence-specific oligo-N-substituted glycine peptidomimetics that emulate the structure and ...
Maxim Lebedev, Aaron B. Benjamin, Sathish Kumar, Natalia Molchanova, Jennifer S. Lin, Kent J. Koster, Julian L. Leibowitz, Annelise E. Barron, Jeffrey D. Cirillo   +8 more
doaj   +1 more source

Self-assembly of bioactive peptides, peptide conjugates, and peptide-mimetic materials [PDF]

, 2017
Molecular self-assembly is a multi-disciplinary field of research, with potential chemical and biological applications. One of the main driving forces of self-assembly is molecular amphiphilicity, which can drive formation of complex and stable ...
Ahmed, Arslan, Bae, Boato, Branco, Brown, Butterfoss, Castelletto, Castelletto, Castelletto, Cavalli, Charlotte J. C. Edwards-Gayle, Cheng, Chu-Kung, Cooke, Cui, Das, Dasgupta, DeForest, Dehsorkhi, Dehsorkhi, Deres, Engler, Fetsch, Fu, Gardner, Guo, Hamley, Hamley, Hamley, Hamley, Hamley, Hamley, Hartgerink, Hartweg, Heinis, Hersel, Hill, Hu, Hubbell, Hutchinson, Hynes, Ian W. Hamley, Jing, Johnson, Jones, Karakoti, Keung, Kiley, Kim, Kirkham, Kita-Tokarczyk, Knop, Kolate, Krug, Lau, Lee, Leupold, Li, Lintner, Liu, Liu, Lutolf, Lutolf, Löwik, Löwik, Makovitzki, Mandal, Marsh, Mas-Moruno, Matson, Matson, Matsuda, Matsumoto, McGregor, Meijer, Middleton, Miller, Miravet, Missirlis, Murnen, Murphy, Nam, Nishiyama, Oku, Pakalns, Pasut, Pelegri-Oday, Peppas, Petka, Place, Place, Qiu, Rice, Robertson, Rosales, Ruoslahti, Ruoslahti, Sanii, Shen, Sheu, Silva, Singh, Slaughter, Spoerke, Stahl, Stendahl, Stupp, Sun, Thiele, Tirrell, Torchilin, Tu, Tysseling-Mattiace, Tzokova, Tzokova, Van Vlierberghe, Vauthey, Wadia, Webster, Wilson, Wiradharma, Wiradharma, Yu, Zhang, Zhao, Zhao, Zhou   +127 more
core   +1 more source

Exploration of the Tertiary Amide Chemical Space of Dolastatin 15 Analogs Reveals New Insights into the Structure–Anticancer Activity Relationship

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
GA: Parallel libraries of novel dolastatin‐like compounds with different N‐substituted backbones were produced using multicomponent reactions as diversification steps. Evaluation of the antiproliferative effect in a variety of cancer cells proved that either the replacement of one proline by a functionalized tertiary amide or introducing a backbone N ...
Dayana Alonso, Leslie Reguera, Robert Rennert, Ibrahim Morgan, Mohammed Saoud, Manuel G. Ricardo, Leslie Valdés, Julieta Coro‐Bermello, Ludger A. Wessjohann, Daniel G. Rivera   +9 more
wiley   +1 more source