Results 91 to 100 of about 9,155,591 (249)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Motivation to Learn as a Mediator of the Relationship between Supervisor Support in Training Programs, Transfer of Competency and Job Performance [PDF]

This study was conducted in oder to measure the effect of the supervisor support and motivation to learn on employee outcomes (i.e., transfer of competency and job performance) using 100 usable questionnaires gathered from technical employees who have ...
Azman ISMAIL, Sofiah BONGOGOH, Sheela Chitra CHANDRA SEGARAN   +2 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Perceived organizational support and attitudes toward organizational change : the moderating role of perceived supervisor support [PDF]

, 2013
Masteroppgave(MSc) in Master of Science in Leadership and Organizational Psychology - Handelshøyskolen BI, 2013Research on organizational change has identified the crucial role of the employees in whether or not a change initiative is successful.
Blom, Lars, Nordli, Jo Andreas
core  

The effects of perceived supervisor support on volunteer satisfaction, motivation and retention in an online text-based emotional support service

, 2023
(1) Objectives. Volunteer retention has been an important issue across the globe. Given the low volunteer retention in the Open Up, an online text-based counselling platform service, the current study attempted to explore the effects of perceived ...
盧卓禮, Lo, Cheuk Lai
core  

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Can Job Crafting Be a Remedy for Struggling With Work Alienation? the Moderator Effect of Perceived Supervisor Support*

, 2022
Aydin, Esra/0000-0003-3302-7691; Aydin, Esra/0000-0003-3302-7691Drawing on self-determination theory, this study focuses on the relationship between job crafting and work alienation and the moderating effect of perceived supervisor support.
Basim, H. Nejat, Aydin, Esra, Cinar, Esra, Nejat Basım, H.   +3 more
core   +1 more source

Supervisor Support as Predictor of Reporting of Physical Symptoms and Psychological Distress among Employees’ Isfahan Steel Company

International Journal of Occupational Hygiene, 2013
Supervisors have critical role in the provision of support in workplace. The present study examined degree of perceived supervisor support related to experienced physical symptoms and psychological distress among employees of Isfahan Steel Company ...
Mohamad Reza Khodabakhsh, Fariba Kiani
doaj  

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source