Results 141 to 150 of about 49,701 (247)

A Case of a Novel Perforin Gene Variant in Severe Familial Hemophagocytic Lymphohistiocytosis Type 2 (FHL2). [PDF]

Case Rep Hematol
Yamauchi H, Hino M, Meguro K, Nakano T, Aoki T, Yamashita Y, Okunushi T, Yamamoto T, Sato H, Yasumi T, Hirata Y, Shibata H, Nakajima H, Hamada H.   +13 more
europepmc   +1 more source

Beyond IHC Stain: Mitochondria as a Histochemical Biomarker for Apoptosis Detection in Hepatic Tissue Sections

Anatomia, Histologia, Embryologia, Volume 55, Issue 2, March 2026.
ABSTRACT Apoptosis plays a critical role in maintaining tissue homeostasis and preventing pathological conditions. The accurate detection of apoptosis is crucial for both research and diagnostic pathology, yet conventional histological staining methods often lack the sensitivity to identify early apoptotic changes.
Maria‐Cătălina Matei‐Lațiu, Andreea Muntean, Vasile Rus, Adrian Florin Gal   +3 more
wiley   +1 more source

Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity. [PDF]

Trends Immunol
Tilburgs T.
europepmc   +1 more source

T‐bet Fate Mapping Reveals Gestational Stage‐Specific Transcriptional Adaptation of Decidual NK Cells

American Journal of Reproductive Immunology, Volume 95, Issue 3, March 2026.
ABSTRACT Problem Natural killer (NK) cells are critical regulators of immune balance at the maternal–fetal interface. T‐bet (Tbx21) is a key transcription factor shaping NK cell effector functions, yet its role in decidual NK (dNK) cell adaptation across gestation remains unclear.
Mona A. Mohamed, Yan Li, Andrea K. Wegrzynowicz, Payton N. Lindner, Jessica Vazquez, Gladys E. Lopez, Aleksandar K. Stanic   +6 more
wiley   +1 more source

IL-21 Selectively Augments Cytotoxic Potential of Antigen-Activated MAIT Cells. [PDF]

Eur J Immunol
Wedlock LE, Lamichhane R, Webley MC, Gilmer SCL, Vernall AJ, Ussher JE.   +5 more
europepmc   +1 more source

Perforin Deficiency [PDF]

, 2020
openaire   +1 more source

Alpha‐Fetoprotein Stimulates Cleavage of Membranal MICA/B on Liver Cancer Cell Lead to Escape Immune Surveillance of Natural Killer Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Hepatocellular carcinoma (HCC) could escape immune surveillance. Alpha‐fetoprotein (AFP) serves as a significant biomarker for HCC; however, its influence on HCC immune surveillance remains elusive. RNA‐Seq data of HCC were obtained from TCGA and GEO databases for the expression of AFP, MICA/B, and related genes.
Xiaowei Li, Siren Feng, Xueqin Wu, Yinglian Pan, Yuli Zhou, Kun Liu, Bo Lin, Wei Li, Mengsen Li, Mingyue Zhu   +9 more
wiley   +1 more source

Pteryxin enhances human NK-cell cytotoxicity by upregulating NKp30, NKp46, and 2B4 via ERK/AKT signaling. [PDF]

Front Pharmacol
Park ES, Kim JT, Hwang YS, Han J, Park HM, Yoon HR, Cho HJ, Lee HG.   +7 more
europepmc   +1 more source

Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation

EMBO Reports, 2017
Imran G. House, C. House, A. Brennan, O. Gilan, M. Dawson, J. Whisstock, R. Law, J. Trapani, I. Voskoboinik   +8 more
semanticscholar   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source