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Structure and Function of Perforin
1988The most striking aspect of lymphocyte-mediated cytolysis is the formation of membrane lesions on target membranes as first described by Dourmashkin et al. (1980). In these early studies, a mixed population of effector cells was used, leaving open the question as to whether the observed membrane lesions were in fact assembled by cytotoxic lymphocytes ...
E R, Podack +3 more
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Addressing the mysteries of perforin function
Immunology & Cell Biology, 2006Perforin is a cytolytic protein stored in secretory granules of CTL and NK cells. It synergizes with proapoptotic serine proteases, granzymes, to deliver the lethal hit to virus‐infected or transformed target cells. The mechanism of perforin action has not been described beyond its original characterization in the 1980s, and its role in human disease ...
Ilia, Voskoboinik, Joseph A, Trapani
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Experimental Parasitology, 2000
CD8+ T cells have been shown to be required for acute resistance to infection with the protozoan parasite, Trypanosoma cruzi, the causative agent of Chagas' disease. However, to date, the mechanism by which CD8+ T cells mediate protection in vivo has not been determined.
S P, Nickell, D, Sharma
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CD8+ T cells have been shown to be required for acute resistance to infection with the protozoan parasite, Trypanosoma cruzi, the causative agent of Chagas' disease. However, to date, the mechanism by which CD8+ T cells mediate protection in vivo has not been determined.
S P, Nickell, D, Sharma
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Gramicidin, VDAC, porin and perforin channels
Current Opinion in Cell Biology, 1990This review covers the miscellaneous channels that do not fall w=ithin the domain of the other reviews in this section. Three different channel systems will be reviewed: the gramicidin A channel; the large weakly selective channels that are present in the outer membrane of mitochondria (VDACs) and bacteria (porin); and the large channels whose function
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Perforin: Structure, Function, and Regulation
1992The mechanism of lymphocyte-mediated cytolysis is controversial (see recent reviews Bleackley et al. 1988; Brunet et al. 1988; Clark et al. 1988; Mueller et al. 1988; Muller-Eberhard 1988; Munger et al. 1988; Nagler-Anderson et al. 1988; Sitkovsky 1988; Young et al. 1988; Podack et al. 1988; Jenne and Tschopp 1988a, b; Bleackley 1988; Hershberger et al.
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Perforin deficiency: fighting unarmed?
Immunology Today, 2000In the June issue of Immunology Today, Stepp and colleagues1xPerforin: more than just an effector molecule. Stepp, S.E. et al. Immunol. Today. 2000; 21: 254–256Abstract | Full Text | Full Text PDF | PubMed | Scopus (96)See all References1 reviewed the growing evidence that perforin, a cytotoxic protein that lymphocytes secrete to kill virus-infected ...
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Perforin and granzymes: function, dysfunction and human pathology
Nature reviews. Immunology, 2015I. Voskoboinik, J. Whisstock, J. Trapani
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Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
Science, 1994D. Kägi +7 more
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Functional significance of the perforin/granzyme cell death pathway
Nature reviews. Immunology, 2002J. Trapani, M. Smyth
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