Results 31 to 40 of about 49,701 (247)
Perforin and lymphohistiocytic proliferative disorders [PDF]
British Journal of Haematology, 2005 SummaryPerforin is critical for cytotoxicity mediated by granules present in natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Perforin‐deficient mice have impaired cytotoxicity by NK cells and CTLs, resulting in failure to control infections with certain viruses or bacteria.
Harutaka, Katano, Jeffrey I, Cohen
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Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption. [PDF]
PLoS ONE, 2014 Numerous neurological disorders are characterized by central nervous system (CNS) vascular permeability. However, the underlying contribution of inflammatory-derived factors leading to pathology associated with blood-brain barrier (BBB) disruption ...
Holly L Johnson +6 more
doaj +1 more source
Frontiers in Immunology, 2018 Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8+ T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic ...
Julia E. Rood +7 more
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The FASEB Journal, 2019 The liver is a central immunologic organ with a high density of myeloid and lymphoid immune cells that play important roles in the development and progression of nonalcoholic steatohepatitis (NASH).
Tianqi Wang +11 more
semanticscholar +1 more source
Perforin and hematological cancer [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 Perforin (PRF) is a soluble cytotoxic pore-forming glycoprotein that is a crucial component of the cocktail of cytotoxic granules harbored by cytotoxic T lymphocytes (CTL) and natural killer cells (NK), collectively known as cytotoxic lymphocytes (CLs).
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Purification of perforin and study expression of perforin in leukemia patient [PDF]
Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 2013 This work aimed to study compare of extraction, purification and study gene expression of perforin from ALL, CLL and healthy, to chive this goal, blood samples were collected from 10 Leukemia cases (5 ALL and 5 CLL) and 5 healthy. Comparison of the molecular weight of purified perforin from these groups shows no detectable differences as compared with ...
Najwa Ahmed +4 more
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Nature Communications, 2017 The connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen ...
Yikun Yao +13 more
semanticscholar +1 more source
Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity
Microorganisms, 2019 An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified.
Eleonora Cimini +12 more
doaj +1 more source
MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections.
JCI Insight, 2017 Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice.
Ryan M. McCormack +8 more
semanticscholar +1 more source
Advanced Science, EarlyView.CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan +10 more
wiley +1 more source