Results 41 to 50 of about 49,701 (247)

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Nature Communications, 2018
CD8 T cells protect the liver against viral infection, but can also cause severe liver damage that may even lead to organ failure. Given the lack of mechanistic insights and specific treatment options in patients with acute fulminant hepatitis, we ...
M. Welz, S. Eickhoff, Zeinab Abdullah, J. Trebicka, Kate H. Gartlan, J. Spicer, A. Demetris, Hedieh Akhlaghi, Martina Anton, K. Manske, D. Zehn, B. Nieswandt, C. Kurts, J. Trapani, P. Knolle, D. Wohlleber, W. Kastenmüller, W. Kastenmüller   +17 more
semanticscholar   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF MICROVESICLES PRODUCED BY NATURAL KILLER CELLS

Медицинская иммунология, 2019
Natural killer (NK) cells are of special interest among a multitude of microvesicle (MV) source cells. NK cells are a lymphocyte subpopulation performing contact cytolysis of virus-infected cells and tumor cells.
D. I. Sokolov, K. L. Markova, V. A. Mikhailova, L. P. Vyazmina, Yu. P. Milyutina, A. R. Kozyreva, A. A. Zhdanova, D. A. Malygina, K. V. Onokhin, A. N. Ivanova, A. V. Korenevsky, S. A. Selkov   +11 more
doaj   +1 more source

Perforin-2 Breaches the Envelope of Phagocytosed Bacteria Allowing Antimicrobial Effectors Access to Intracellular Targets

Journal of Immunology, 2018
Perforin-2, the product of the MPEG1 gene, limits the spread and dissemination of bacterial pathogens in vivo. It is highly expressed in murine and human phagocytes, and macrophages lacking Perforin-2 are compromised in their ability to kill phagocytosed
Fangfang Bai, Ryan M. McCormack, Suzanne Hower, G. Plano, M. Lichtenheld, G. Munson   +5 more
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection

Frontiers in Immunology, 2016
In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response.
Maja eArapovic, Ilija eBrizic, Branka ePopovic, Slaven eJurkovic, Stefan eJordan, Astrid eKrmpotic, Jurica eArapovic, Jurica eArapovic, Stipan eJonjic, Stipan eJonjic   +9 more
doaj   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

The CML experience to elucidate the role of innate T-cells as effectors in the control of residual cancer cells and as potential targets for cancer therapy

Frontiers in Immunology
Considering the general view that unconventional immune effectors play a major role in antitumor immunity, we recently postulated that the distinct new innate CD8 T-cell pool (co-expressing the transcription factor Eomesodermin and innate markers such as
Amandine Decroos, Amandine Decroos, Sarah Meddour, Sarah Meddour, Marine Demoy, Marine Demoy, Nathalie Piccirilli, Nathalie Piccirilli, Philippe Rousselot, Philippe Rousselot, Philippe Rousselot, Franck E. Nicolini, Franck E. Nicolini, Stéphanie Ragot, Jean-Marc Gombert, Jean-Marc Gombert, André Herbelin, Alice Barbarin, Emilie Cayssials, Emilie Cayssials, Emilie Cayssials, Emilie Cayssials   +21 more
doaj   +1 more source

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function

Frontiers in Immunology, 2013
Congenital perforin deficiency is considered a rare cause of human immunopathology and immune dysregulation, and classically presents as a fatal illness early in infancy.
Joseph A. Trapani, Ilia eVoskoboinik
doaj   +1 more source

Coordinated In Vitro Release of Granulysin, Perforin and IFN-γ in TB and HIV/TB Co-Infection Associated with Clinical Outcomes before and after Anti-TB Treatment

Pathogens, 2020
Granule-associated killing molecules released from cytotoxic T lymphocytes participate as a crucial step in immunity against tuberculosis (TB), but the role of coordinated production remains controversial.
Nada Pitabut, Panadda Dhepakson, Shinsaku Sakurada, Naoto Keicho, Srisin Khusmith   +4 more
doaj   +1 more source