Results 61 to 70 of about 49,701 (247)

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

Clinico-laboratory profile and perforin gene mutations of pediatric hemophagocytic lymphohistiocytosis cases: a five-year single center study

The Pan African Medical Journal, 2020
INTRODUCTION: Hemophagocytic lymphohistocytosis (HLH) is an immunological disease characterized by hemophagocytosis of blood cells and proliferation of T-cells and histiocytes in the spleen and bone marrow then infiltration into body organs. Familial HLH
Mohamed Abdelkader Almalky, Safaa Hamdy Ahmad Saleh, Eman Gamal Baz, Ahmed Elsadek Fakhr   +3 more
doaj   +1 more source

Perforin deficiency attenuates collagen-induced arthritis [PDF]

Arthritis Research & Therapy, 2005
AbstractCollagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesis of CIA. They probably contribute to certain features of disease, namely tissue destruction and synovial hyperplasia.
Bauer, Kristin, Knipper, Annika, Tu-Rapp, Hoang, Koczan, Dirk, Kreutzer, Hans-Jürgen, Nizze, Horst, Mix, Eilhard, Thiesen, Hans-Juergen, Holmdahl, Rikard, Ibrahim, Saleh M   +9 more
openaire   +2 more sources

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Serum immune modulators during the first cycle of anti‐PD‐1 antibody therapy in non‐small cell lung cancer: Perforin as a biomarker

Thoracic Cancer, 2020
Background Currently used biomarkers for immunotherapy are inadequate because they are only based on tumor properties. In view of microenvironment changes by tumors, host immunity should be considered, which may result in identifying more accurate and ...
Takayo Ota, Tomoya Fukui, Yoshiro Nakahara, Takayuki Takeda, Junji Uchino, Takako Mouri, Keita Kudo, Saki Nakajima, Tomohiro Suzumura, Masahiro Fukuoka   +9 more
doaj   +1 more source

Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD

Frontiers in Immunology, 2020
Non-alcoholic fatty liver disease (NAFLD) is one of the main causes of cirrhosis and major risk factors for hepatocellular carcinoma and liver-related death.
Qian Wang, Qian Wang, Dehai Li, Dehai Li, Jing Zhu, Jing Zhu, Mingyue Zhang, Mingyue Zhang, Hua Zhang, Hua Zhang, Guangchao Cao, Guangchao Cao, Leqing Zhu, Leqing Zhu, Qiping Shi, Jianlei Hao, Jianlei Hao, Qiong Wen, Qiong Wen, Zonghua Liu, Zonghua Liu, Hengwen Yang, Hengwen Yang, Zhinan Yin, Zhinan Yin   +24 more
doaj   +1 more source

Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Open Biology, 2016
The vertebrate-specific proteins astrotactin-1 and 2 (ASTN-1 and ASTN-2) are integral membrane perforin-like proteins known to play critical roles in neurodevelopment, while ASTN-2 has been linked to the planar cell polarity pathway in hair cells ...
T. Ni, K. Harlos, R. Gilbert
semanticscholar   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Candida albicans Induces Metabolic Reprogramming in Human NK Cells and Responds to Perforin with a Zinc Depletion Response

Frontiers in Microbiology, 2016
As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
D. Hellwig, Jessica Voigt, Maria Bouzani, J. Löffler, D. Albrecht-Eckardt, Michael Weber, S. Brunke, Ronny Martin, O. Kurzai, Kerstin Hünniger   +9 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source