Results 1 to 10 of about 3,626 (130)

Neonatal Zika virus infection causes transient perineuronal net degradation [PDF]

Frontiers in Cellular Neuroscience, 2023
Perineuronal nets (PNNs) form a specialized extracellular matrix that predominantly surrounds parvalbumin (PV)-expressing GABAergic inhibitory interneurons and help regulate neuronal activity. Their formation early in the postnatal period is regulated by
Kaliroi Engel, Ha-Na Lee, Bhanu P. Tewari, Aaron P. Lewkowicz, Derek D. C. Ireland, Mohanraj Manangeeswaran, Daniela Verthelyi   +6 more
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Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus [PDF]

Neural Regeneration Research, 2022
Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements, posture and vegetative functions. After a shorter or longer period of time, the vestibular function is partially or completely restored via a series of ...
Agnes Magyar, Eva Racz, Clara Matesz, Ervin Wolf, Peter Kiss, Botond Gaal   +5 more
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Perineuronal Net Receptor PTPσ Regulates Retention of Memories [PDF]

Frontiers in Synaptic Neuroscience, 2021
Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long ...
Angelina Lesnikova, Plinio Casarotto, Rafael Moliner, Senem Merve Fred, Caroline Biojone, Eero Castrén   +5 more
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Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure [PDF]

BMC Biology, 2022
Background Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such as brain plasticity and memory, and
Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto, Sophie Lenoir, Caroline Regnauld, Elsa Pouettre, Juliette Piquet, Laurent Lebouvier, Yannick Hommet, Eric Maubert, Véronique Agin, Bertrand Lambolez, Bruno Cauli, Carine Ali, Denis Vivien   +15 more
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Update on Perineuronal Net Staining With Wisteria floribunda Agglutinin (WFA) [PDF]

Frontiers in Integrative Neuroscience, 2022
As chemically specialized forms of the extracellular matrix in the central nervous system, polyanionic perineuronal nets (PNs) contain diverse constituents, including chondroitin sulfate proteoglycans (CSPGs), hyaluronic acid, and tenascins.
Wolfgang Härtig, Anton Meinicke, Dominik Michalski, Stefan Schob, Carsten Jäger, Carsten Jäger   +5 more
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Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay [PDF]

Molecular Brain
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1.
Dylan J. Terstege, Duneesha Goonetilleke, Cindy K. Barha, Jonathan R. Epp   +3 more
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Region-Specific Alterations of Perineuronal Net Expression in Postmortem Autism Brain Tissue [PDF]

Frontiers in Molecular Neuroscience, 2022
Genetic variance in autism spectrum disorder (ASD) is often associated with mechanisms that broadly fall into the category of neuroplasticity. Parvalbumin positive neurons and their surrounding perineuronal nets (PNNs) are important factors in critical ...
Cheryl Brandenburg, Cheryl Brandenburg, Gene J. Blatt   +2 more
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Age-related inflammatory changes and perineuronal net dynamics: implications for aging [PDF]

Journal of Neuroinflammation
Background Healthy aging alone can lead to cognitive decline, decreased brain size, protein aggregation, accumulation of senescent cells and neuroinflammation.
Zachary A. Colon, Shannon C. Chan, Kathleen A. Maguire-Zeiss   +2 more
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Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation [PDF]

Translational Psychiatry
Post-retrieval extinction has been effective in erasing recent pathological memories but has been shown failed in erasing remote memories. Pathological memories are often formed over the long term, therefore how to erase the remote pathological memory ...
Shuai-Wen Teng, Wen-Bo Guo, Bing-Feng Song, Yun-Zhang He, Ke-Yan Wang, Shi-Bin Gao, Wei Li, Zhe-Yu Chen   +7 more
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Perineuronal Net Alterations Following Early-Life Stress: Are Microglia Pulling Some Strings? [PDF]

Biomolecules
The extracellular matrix plays a key role in synapse formation and in the modulation of synaptic function in the central nervous system. Recent investigations have revealed that microglia, the resident immune cells of the brain, are involved in ...
Reza Rahimian, Claudia Belliveau, Sophie Simard, Gustavo Turecki, Naguib Mechawar   +4 more
doaj   +2 more sources