A neural extracellular matrix-based method for in vitro hippocampal neuron culture and dopaminergic differentiation of neural stem cells [PDF]
, 2013 BACKGROUND: The ability to recreate an optimal cellular microenvironment is critical to understand neuronal behavior and functionality in vitro.
Adolfo López de Munain +7 more
core +3 more sources
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, Volume 9, Issue 12, December 2025.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects [PDF]
, 2017 Diverse molecular mechanisms regulate synaptic composition and function in the mammalian nervous system. The multifunctional protein arginine methyltransferase 8 (PRMT8) possesses both methyltransferase and phospholipase activities.
Elmsaouri, Sara +7 more
core +1 more source
The critical role of extracellular matrix in Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background In central nervous system, all components are enveloped by the extracellular matrix (ECM), regulating microenvironmental homeostasis and neuronal development. The condensed cartilage‐like ECM called perineuronal nets (PNNs), mainly surrounding parvalbumin‐expressing (PV+) fast‐firing GABAergic interneurons, are crucial to synaptic ...
Xiaolei Zhu, Zhen Lan, Yun Xu
wiley +1 more source
Combined Chondroitinase and KLF7 Expression Reduce Net Retraction of Sensory and CST Axons from Sites of Spinal Injury [PDF]
, 2017 Axon regeneration in the central nervous system is limited both by inhibitory extracellular cues and by an intrinsically low capacity for axon growth in some CNS populations.
Blackmore, Murray G. +4 more
core +1 more source
Cavitation Induction by Projectile Impacting on a Water Jet [PDF]
, 2019 The present paper focuses on the simulation of the high-velocity impact of a projectile impacting on a water-jet, causing the onset, development and collapse of cavitation. The simulation of the fluid motion is carried out using an explicit, compressible,
Farhat, M. +4 more
core +1 more source
Role of perineuronal nets in Alzheimer's Disease‐associated social memory impairment
Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting approximately 55 million people worldwide. Key pathological features of AD include the accumulation of beta‐amyloid plaques and hyperphosphorylated tau tangles.
Lata Chaunsali
wiley +1 more source
iScienceSummary: Visual cortical plasticity is high during early life, but gradually decreases with development. This is due to the Otx2-driven maturation of intracortical inhibition that parallels the condensation of extracellular matrix components into ...
Dmytro Shmal +4 more
doaj +1 more source
Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons
Frontiers in Cellular Neuroscience, 2018 Neurocan is a chondroitin sulfate proteoglycan present in perineuronal nets, which are associated with closure of the critical period of synaptic plasticity.
Vishwa Mohan +8 more
doaj +1 more source
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis [PDF]
, 2016 S1 IHC in pre-symptomatic and clinical-onset EAE: PV+ cell counts, PNN counts, and Iba-1+ microglia counts. A) Representative fluorescence photomicrographs of PV+ staining (low-mag) in S1 from control (CFA) and EAE animals at the pre-symptomatic stage (7–
Bradley J. Kerr +8 more
core +4 more sources