Results 11 to 20 of about 3,695 (191)

The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders [PDF]

Frontiers in Molecular Neuroscience, 2018
Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates that PV cells and PNN are impaired in a variety of neurological disorders.
Teresa H. Wen, Devin K. Binder, Devin K. Binder, Iryna M. Ethell, Iryna M. Ethell, Khaleel A. Razak, Khaleel A. Razak   +6 more
doaj   +5 more sources

Caught in the Net: Perineuronal Nets and Addiction [PDF]

Neural Plasticity, 2016
Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories. These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction ...
Megan Slaker, Jordan M. Blacktop, Barbara A. Sorg   +2 more
doaj   +4 more sources

Minimally invasive protocols and quantification for microglia-mediated perineuronal net disassembly in mouse brain [PDF]

STAR Protocols, 2021
Summary: Enzymatic digestion of the extracellular matrix with chondroitinase-ABC reinstates juvenile-like plasticity in the adult cortex as it also disassembles the perineuronal nets (PNNs).
Alessandro Venturino, Sandra Siegert
doaj   +2 more sources

Shock-Induced Damage Mechanism of Perineuronal Nets [PDF]

Biomolecules, 2021
The perineuronal net (PNN) region of the brain’s extracellular matrix (ECM) surrounds the neural networks within the brain tissue. The PNN is a protective net-like structure regulating neuronal activity such as neurotransmission, charge balance, and ...
Khandakar Abu Hasan Al Mahmud, Fuad Hasan, Md Ishak Khan, Ashfaq Adnan   +3 more
doaj   +4 more sources

Assessing translational applicability of perineuronal net dysfunction in Alzheimer’s disease across species [PDF]

Frontiers in Neuroscience
In the context of aging and age-associated neurodegenerative disorders, the brain’s extracellular matrix (ECM) serves as a critical regulator for neuronal health and cognitive function.
Aarun S. Hendrickson, Aarun S. Hendrickson, Kendra L. Francis, Kendra L. Francis, Asmit Kumar, Asmit Kumar, Jaden P. Le, Jaden P. Le, Jarrad M. Scarlett, Jarrad M. Scarlett, C. Dirk Keene, David A. Tovar, Kimberly M. Alonge, Kimberly M. Alonge   +13 more
doaj   +2 more sources

Assessment of Possible Contributions of Hyaluronan and Proteoglycan Binding Link Protein 4 to Differential Perineuronal Net Formation at the Calyx of Held [PDF]

Frontiers in Cell and Developmental Biology, 2021
The calyx of Held is a giant nerve terminal mediating high-frequency excitatory input to principal cells of the medial nucleus of the trapezoid body (MNTB).
Kojiro Nojima, Haruko Miyazaki, Tetsuya Hori, Lydia Vargova, Lydia Vargova, Toshitaka Oohashi   +5 more
doaj   +2 more sources

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

Cell Reports, 2021
Summary: The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance.
Sara Kohnke, Sophie Buller, Danae Nuzzaci, Katherine Ridley, Brian Lam, Helena Pivonkova, Marie A. Bentsen, Kimberly M. Alonge, Chao Zhao, John Tadross, Staffan Holmqvist, Takahiro Shimizo, Hannah Hathaway, Huiliang Li, Wendy Macklin, Michael W. Schwartz, William D. Richardson, Giles S.H. Yeo, Robin J.M. Franklin, Ragnhildur T. Karadottir, David H. Rowitch, Clemence Blouet   +21 more
doaj   +2 more sources

Circadian Rhythms of Perineuronal Net Composition. [PDF]

eNeuro, 2020
Abstract Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that envelop neurons and regulate synaptic functions. Long thought to be stable structures, PNNs have been recently shown to respond dynamically during learning, potentially regulating the formation of new synapses. We postulated that PNNs
Pantazopoulos H, Pantazopoulos H, Gisabella B, Rexrode L, Benefield D, Yildiz E, Seltzer P, Valeri J, Chelini G, Reich A, Ardelt M, Berretta S.   +11 more
europepmc   +5 more sources

Perineuronal Net Dynamics in the Pathophysiology of Epilepsy. [PDF]

Epilepsy Curr, 2021
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can be reversed by experimental ...
Chaunsali L, Tewari BP, Sontheimer H.
europepmc   +5 more sources

Perineuronal net degradation in epilepsy [PDF]

Epilepsia, 2015
SummaryObjectiveWe previously reported loss of perineuronal net (PN) immunohistochemical staining around parvalbumin‐positive interneurons in the hippocampus of rats after an episode of status epilepticus (SE). We hypothesized that the loss of thePNcould alter seizure susceptibility and that matrix metalloproteinases (MMPs) were candidates for ...
Elyse K. Rankin‐Gee, Paulette A. McRae, Esther Baranov, Stephanie Rogers, Luke Wandrey, Brenda E. Porter   +5 more
openaire   +2 more sources