Results 31 to 40 of about 3,695 (191)
Biomolecules, 2021 Because of their abilities to catalyze generation of toxic free radical species, free concentrations of the redox reactive metals iron and copper are highly regulated.
Jessica A. Burket +2 more
doaj +1 more source
Perineuronal nets stabilize the grid cell network [PDF]
Nature Communications, 2019 AbstractGrid cells are part of a widespread network that supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons.
Ane Charlotte Christensen +7 more
openaire +6 more sources
Proteoglycan Sulphation in the Function of the Mature Central Nervous System
Frontiers in Integrative Neuroscience, 2022 Chondroitin sulphate and heparan sulphate proteoglycans (CSPGS and HSPGs) are found throughout the central nervous system (CNS). CSPGs are ubiquitous in the diffuse extracellular matrix (ECM) between cells and are a major component of perineuronal nets ...
James W. Fawcett +3 more
doaj +1 more source
Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin. [PDF]
, 2014 The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical interneurons: Reln coding for reelin ...
A Bernard +43 more
core +2 more sources
A „ruha” teszi a neuront – az extracelluláris mátrix különböző megjelenési formái gerincesek központi idegrendszerében [PDF]
, 2013 Introduction: Extracellular matrix is a key component of most connective tissues. For decades, the presence of this chemically heterogeneous interface has been largely unaddressed or even denied in the central nervous system.
Gáti, Georgina, Lendvai, Dávid
core +1 more source
Releasing Addiction Memories Trapped in Perineuronal Nets [PDF]
Trends in Genetics, 2018 Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse.
Amy W. Lasek, Hu Chen, Wei-Yang Chen
openaire +2 more sources
Perineuronal Nets: Subtle Structures with Large Implications
The Neuroscientist, 2022 Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround the soma and proximal dendrites of certain neurons in the central nervous system, particularly parvalbumin-expressing interneurons. Their appearance overlaps the maturation of neuronal circuits and the closure of critical periods in different regions of the ...
Héctor Carceller +3 more
openaire +5 more sources
Neurobiology of Disease, 1999 GABA-interneurons immunoreactive (IR) for the calcium-binding protein parvalbumin are lost during the early stages of Creutzfeldt-Jakob disease (CJD) and diminution in their number may partially account for the neurological disturbances manifested in ...
Pavel V. Belichenko +4 more
doaj +1 more source
Perineuronal Nets and CNS Plasticity and Repair [PDF]
Neural Plasticity, 2016 The extracellular matrix (ECM) of the nervous system regulates numerous events during development, from neurogenesis and gliogenesis to circuitry formation, as well as in adulthood, affecting damage responses, plasticity, and regeneration. Substantial changes in the quantity and the composition of ECM occur during development.
CARULLI, Daniela +2 more
openaire +6 more sources
A Periaxonal Net in the Zebrafish Central Nervous System [PDF]
, 2003 We produced a monoclonal antibody, named A20, which specifically recognizes a 35 kDa protein and stains myelinated axons in zebrafish brain. The A20 antigen is located at the outside of the myelin layer of large axons, and comprises a fine meshwork ...
Alfei +19 more
core +1 more source