Results 61 to 70 of about 3,695 (191)

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]

, 2016
Background A reduction of the number of parvalbumin (PV)-immunoreactive (PV⁺) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK
Filice, Federica, Schwaller, Beat, Sungur, Ayse Özge, Vörckel, Karl Jakob, Wöhr, Markus   +4 more
core   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Trends in Neurosciences, 2019
The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key
Reichelt, Amy C., Hare, Dominic J., Bussey, Timothy J., Saksida, Lisa M.   +3 more
openaire   +4 more sources

Developmental patterns of extracellular matrix molecules in the embryonic and postnatal mouse hindbrain

Frontiers in Neuroanatomy
Normal brain development requires continuous communication between developing neurons and their environment filled by a complex network referred to as extracellular matrix (ECM). The ECM is divided into distinct families of molecules including hyaluronic
Ildikó Wéber, Adél Dakos, Zoltán Mészár, Clara Matesz, Clara Matesz, András Birinyi   +5 more
doaj   +1 more source

Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System

Frontiers in Cellular Neuroscience, 2021
Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with.
Chia-Chien Chen, Chia-Chien Chen, Joshua C. Brumberg, Joshua C. Brumberg   +3 more
doaj   +1 more source

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer's disease. [PDF]

, 2019
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD), increasing risk and decreasing age of disease onset. Many studies have demonstrated the detrimental effects of apoE4 in varying cellular contexts.
Huang, Yadong, Jones, Emily A, Najm, Ramsey   +2 more
core   +1 more source

Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]

, 2013
Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence. [PDF]

Int J Mol Sci
Perineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations of CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer’s disease, stroke, post-traumatic conditions, and some other brain disorders.
Paveliev M, Egorchev AA, Musin F, Lipachev N, Melnikova A, Gimadutdinov RM, Kashipov AR, Molotkov D, Chickrin DE, Aganov AV.   +9 more
europepmc   +3 more sources

Postnatal development of the microstructure of cortical GABAergic synapses and perineuronal nets requires sensory input [PDF]

, 2022
The brain synaptic circuitry is formed as a result of pre-defined genetic programs and sensory experience during postnatal development. Perineuronal nets ensheath synaptic boutons and control several crucial features of the synapse physiology.
Aganov, Albert, Arnst, Nikita, Dvoeglazova, Anastasia, Fedosimova, Svetlana, Kiyasov, Andrei, Kochneva, Anastasia, Lipachev, Nikita, Mavlikeev, Mikhail, Melnikova, Anastasia, Osin, Yuri, Paveliev, Mikhail, Shaikhutdinov, Nurislam, Titova, Angelina   +12 more
core   +1 more source