Results 71 to 80 of about 3,695 (191)

Loss of Perineuronal Net in ME7 Prion Disease [PDF]

Journal of Neuropathology & Experimental Neurology, 2008
Microglial activation and behavioral abnormalities occur before neuronal loss in experimental murine prion disease; the behavioral changes coincide with a reduction in synaptic plasticity. Because synaptic plasticity depends on an intact perineuronal net (PN), a specialized extracellular matrix that surrounds parvalbumin (PV)-positive GABAergic (gamma ...
Franklin, SL, Love, S, Greene, JRT, Betmouni, S   +3 more
openaire   +3 more sources

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization

Frontiers in Cell and Developmental Biology, 2021
Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan, Kelsey E. Murphy, Patricia F. Maness   +2 more
doaj   +1 more source

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? [PDF]

, 2016
Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to abnormal neurodevelopmental trajectories, affecting local neuronal networks and ...
A. Monin, Abekawa, Atallah, Atkuri, Avshalumov, Back, Baker, Ballesteros, Bartos, Baud, Behrens, Behrens, Belforte, Bentsen, Berk, Berk, Beurdeley, Bilbo, Bodhinathan, Brenhouse, Bridges, Brown, Buckholtz, Buelna-Chontal, Bulut, Byne, Cabungcal, Cabungcal, Cabungcal, Cadet, Cai, Callahan, Cao, Cardin, Carlen, Carlson, Carmeli, Cavaliere, Chattopadhyaya, Chew, Choi, Clay, Cleland, Corcoba, Coyle, Cyr, D. Dwir, Dalmau, das Neves Duarte, Davis, Dell'Anna, Dickerson, Dityatev, Do, Do, Do, Do, Donato, Eluvathingal, Fan, Fan, Fan, Farokhnia, Farr, Fazzari, Fitzsimmons, Fournier, Fragoso, French, Fries, Fromer, Fuchs, Fukuda, Gandal, Garate, Gawryluk, Gokhale, Goldshmit, Gravina, Gulyas, Gysin, Gysin, Hakak, Hardingham, Harris, Harris, Harte, Hikida, Hof, Hoftman, Homayoun, Huang, Hwang, Ibi, Insel, J.H. Cabungcal, Jana, Javitt, Jenkins, Jiang, Jiang, Johnson, Jones, K.Q. Do, Kann, Kantrowitz, Katsel, Kaur, Kerns, Kettenmann, Kinney, Kirov, Kocsis, Koga, Kohr, Komitova, Korotkova, Krishnan, Krystal, Kulak, Kulak, Kyriakopoulos, Lante, Lataster, Lataster, Lavoie, Lavoie, Lazarewicz, Lewis, Leza, Li, Li, Lisman, Liu, Lodge, Lodge, Lucas, Lutgen, M. Cuenod, Makinodan, Makinodan, Mandal, Martins-de-Souza, Massi, Mauney, McGee, McNally, Mehta, Meiser, Meyer, Meyer, Meyer, Miyata, Mizrahi, Moller, Monin, Morishita, Morishita, Muller, Muller, Mustafa, Myin-Germeys, Myin-Germeys, O'Donnell, O'Donnell, Oorschot, Otte, P. O'Donnell, P. Steullet, Paintlia, Pantazopoulos, Papadia, Park, Patz, Penschuck, Pinteaux, Pitts, Poels, Potvin, Powell, Purcell, Rabinovic, Ray, Reddy, Robinson, Rodriguez-Santiago, Rotaru, Rouhinen, Roux, Saetre, Schiavone, Shirai, Sinn, Smith, Smyth, Sohal, Song, Stefansson, Steiner, Steullet, Steullet, Steullet, Steullet, Stevens, Stojkovic, Sullivan, Takahashi, Takao, Timms, Tkachev, Tosic, Tseng, Tseng, Uhlhaas, Uhlhaas, Umbricht, Uranova, Uranova, Uranova, Valko, van Berckel, Vinson, Walter, Wang, Wang, Wang, Wang, Wang, Wen, Whitford, Wulff, Yanagi, Yao, Yao, Zafarullah, Zhang, Zhang, Zhang   +237 more
core   +1 more source

MR Elastography-Based Assessment of Matrix Remodeling at Lesion Sites Associated With Clinical Severity in a Model of Multiple Sclerosis [PDF]

, 2020
Magnetic resonance imaging (MRI) with gadolinium based contrast agents (GBCA) is routinely used in the clinic to visualize lesions in multiple sclerosis (MS).
Boehm-Sturm, Philipp, Gil-Infante, Ana, Guo, Jing, Hanke-Vela, Laura, Infante-Duarte, Carmen, Malla, Bimala, Millward, Jason M., Mueller, Susanne, Pilch, Kjara, Sack, Ingolf, Waiczies, Sonia, Wang, Shuangqing   +11 more
core   +2 more sources

WFA-labeled perineuronal nets in the macaque claustrum [PDF]

Claustrum, 2018
The claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.We report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal
Mihovil Pletikos, Kathleen S. Rockland
openaire   +2 more sources

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

How Stress Influences the Dynamic Plasticity of the Brain’s Extracellular Matrix

Frontiers in Cellular Neuroscience, 2022
Diffuse and structured extracellular matrix (ECM) comprise ∼20% of the brain’s volume and play important roles in development and adult plasticity. Perineuronal nets (PNNs), specialized ECM structures that surround certain types of neurons in the brain ...
Blake J. Laham, Elizabeth Gould
doaj   +1 more source

The Genetic Signature of Perineuronal Oligodendrocytes [PDF]

, 2008
Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it was proposed that following injury, they may remyelinate
Dragan Maric, Gabor Lovas, Javier Martinez de Velasco, Joseph A. Nielsen, Lynn D. Hudson, Sara Szuchet   +5 more
core   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source