Results 171 to 180 of about 45,110 (263)

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

MSMO1 promotes chemotherapy resistance through modulation of T-MAS metabolism via PERK/elF2α/ATF4/CHOP pathway. [PDF]

iScience
Ren H, Wang X, Shao Z, Xiong M, Chi W, Sang Y, Zhang Q, Wang Z, Liu D, Zhang L, Chen M, Zhu H, Xue J, Xiu B, Chi Y, Wu J.   +15 more
europepmc   +1 more source

From Redox Imbalance to Tissue Injury: Insights Into Antidepressant Drug Amitriptyline Effects on Salivary Glands

Cell Biochemistry and Function, Volume 44, Issue 3, March 2026.
ABSTRACT This study aimed to investigate the effects of amitriptyline administration on the salivary glands and saliva of rats. Twenty‐eight male Wistar rats (60 days old) were divided into two groups (n = 14 per group): control and amitriptyline‐treated (10 mg/kg/day for 30 days).
Cristian dos Santos Pereira, Deiweson Souza‐Monteiro, Yago Gecy de Sousa Né, Jorddy Neves da Cruz, Vinicius Ruan Neves dos Santos, Everton Luiz Pompeu Varela, Sandro Percário, Leonardo Oliveira Bittencourt, Antonio Hernandes Chaves‐Neto, Rafael Rodrigues Lima   +9 more
wiley   +1 more source

Interaction between transient receptor potential vanilloid 4 and glutamate NMDA receptor subunit 1 mediates endoplasmic reticulum stress and neuroinflammation in postoperative delirium. [PDF]

Mol Biomed
Huang S, Zhang T, Wang Y, Du H, He J, Zeng H, Ma L, Deng D, Zhou Y, Liu S, Zhao W, Yang X, Han L, Zhao S, Shu S, Yao S, Zhong Q, Chen X, Wang J.   +18 more
europepmc   +1 more source

Measuring the Sustainability Performance of Tech Companies: Scale Development Approach for Achieving Corporate Social Responsibility

Corporate Social Responsibility and Environmental Management, Volume 33, Issue 2, Page 1740-1756, March 2026.
ABSTRACT The European Union (EU) has consistently advanced sustainability goals, with the 2019 European Green Deal (EGD) serving as a cornerstone initiative aligned with global sustainability frameworks. Yet, the combined impact of the Covid‐19 pandemic, energy market volatility, and supply chain disruptions has amplified the urgency of evaluating ...
Edoardo Crocco, Laura Broccardo, Hind Alofaysan, Dhruv Galgotia   +3 more
wiley   +1 more source

Role of abnormal phosphatidylcholine metabolism in endoplasmic reticulum stress-induced carotid artery plaque destabilization. [PDF]

Atheroscler Plus
Hu Q, Zhang H, Wang X, Huang J, Jiang X, Li M, Chen D.   +6 more
europepmc   +1 more source

Integration of single‐cell and bulk transcriptomics reveals the association of manganese metabolism‐related genes with prognosis and immune infiltration in lung adenocarcinoma

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
This study developed a prognostic model for lung adenocarcinoma using manganese metabolism‐related genes (MRGs). Nine key MRGs were identified via multi‐omics and LASSO‐Cox analyses to calculate a risk score. The model showed robust predictive performance in both training and validation cohorts.
Hongliang Li, Shuzhen Wei, Wei Li, Junxia Sun, Yi Wang   +4 more
wiley   +1 more source

Endoplasmic Reticulum Stress Mediates Axon Initial Segment Shortening: Implications for Diabetic Brain Complications. [PDF]

J Mol Neurosci
Shelby JN, Chisholm AM, Akhmedov I, Sheriff N, Griggs RB, Susuki K.   +5 more
europepmc   +1 more source

Morphological instability in restored intertidal flats: How anthropogenic structures drive early‐stage evolution

Earth Surface Processes and Landforms, Volume 51, Issue 3, March 2026.
The study focusses on the morphological evolution of worldwide restored intertidal flats. These intertidal flats initially experience high sedimentation rates after the opening of the connection with open waters. The anthropogenic structures cause high morphological instability and are eroded, leading to a self‐cannibalisation of the system.
Riccardo Brunetta, Samantha Crowell, Megan Elliott, Danika van Proosdij, Paolo Ciavola   +4 more
wiley   +1 more source