Results 11 to 20 of about 45,110 (263)
Severe Wolcott-Rallison syndrome due to a nonsense mutation in the first exon EIF2AK3
Сахарный диабет, 2018 Wolcott-Rallison syndrome is a rare autosomal recessive disease characterized by neonatal diabetes mellitus in combination with osteodysplasia and liver failure.
Diliara N. Gubaeva +3 more
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eLife, 2015 The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis.
Marta Carrara +4 more
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Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]
Medicinski PodmladakEndoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka +1 more
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The Reflection of Positivism to German Literature / Pozitivizmin Alman Edebiyatına Yansıması [PDF]
Folklor/Edebiyat, 2018 Towards the end of the19th century, there had been many social and economic changes and these changes had effects upon the public which could be regarded as negative.
Derya Perk
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Development of a cell-free screening assay for the identification of direct PERK activators.
PLoS ONE, 2023 The activation of the unfolded protein response, particularly via the PERK pathway, has been suggested as a promising therapeutic approach in tauopathies, a group of neurodegenerative disorders characterized by the abnormal phosphorylation and ...
Márcia F D Costa +2 more
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Scientific Reports, 2021 Endoplasmic reticulum (ER) stress plays an important role in hepatocyte degeneration, especially in patients with chronic liver injury. Protein kinase R-like endoplasmic reticulum kinase (PERK) is a key molecule in ER stress.
Atsushi Yukimoto +10 more
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Diabetes, Metabolic Syndrome and Obesity, 2020 Xiaohui Xu,1,2,* Biao Chen,3,* Qichun Huang,1 Yani Wu,4 Tao Liang5 1Department of Pharmacy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People’s Republic of China; 2Institute of Cancer Prevention and Treatment ...
Xu X, Chen B, Huang Q, Wu Y, Liang T
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The Prognostic Value of PERK in Cancer and Its Relationship With Immune Cell Infiltration
Frontiers in Molecular Biosciences, 2021 Background: Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a type I transmembrane protein that functions as an endoplasmic reticulum (ER) stress sensor to regulate global protein synthesis.
Peng Wang +6 more
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PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
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PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. [PDF]
PLoS Genetics, 2016 The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both ...
Dariusz Pytel +14 more
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