Results 61 to 70 of about 45,110 (263)

Where Do We Fit? Reflections on Research Interview Practice, Project Design, and Interpretation**

Berichte zur Wissenschaftsgeschichte, EarlyView.
What is special about historical research interviews in the history of science, technology, and medicine, and how do they compare to the tools of oral historians and social scientists? This essay reflects on three interview projects I have undertaken, each taking a distinct shape.
Dmitriy Myelnikov
wiley   +1 more source

ER stress tolerance is regulated by copper-dependent PERK kinase activity

Cell Reports
Summary: Pancreatic/PKR-like endoplasmic reticulum (ER) kinase (PERK) is a kinase that, in response to ER stress, mediates dual homeostatic and pro-apoptotic signaling. Thus, intricate regulation is required for physiological function.
Sarah E. Bond Newton, Xinglong Shi, Noah R. Beratan, Julia Perhacs, Jitendra K. Arya, Margaret K. Bond, Tali Gidalevitz, Cagla Akay-Espinoza, Donita C. Brady, Kelly L. Jordan-Sciutto   +9 more
doaj   +1 more source

Family Involvement and Financial Performance: How Do They Affect the Sustainability Commitment of Family Businesses?

Business Strategy and the Environment, EarlyView.
ABSTRACT The socio‐emotional wealth (SEW) perspective suggests that the specific priorities of a family business may make it more or less inclined to engage in sustainable practices. This paper examines how family business heterogeneity regarding family ownership, financial performance, and family board members affects the sustainability commitment of ...
Sonia Sánchez‐Andújar, Purificación Parrado‐Martínez, María Comino‐Jurado   +2 more
wiley   +1 more source

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

ER stress sensor PERK drives ferroptosis by disrupting MAMs-mediated mitochondrial homeostasis and promoting mtROS accumulation in acute myocardial infarction

Pharmacological Research
Acute myocardial infarction (AMI) is a life-threatening condition in which ferroptosis represents an important form of regulated cardiomyocyte death, yet its upstream regulatory mechanisms remain incompletely understood.
Xueshu Tao, Yunxiang Zhang, Jiao Pang, Zihan Liao, Gaohan Chen, Xue Zhong, Xingrui Cao, Ying Lin, Dawei Guan, Yuan Tian, Liang Hao, Rui Zhao, Zhipeng Cao   +12 more
doaj   +1 more source

Gye & Perkes v McIntyre [PDF]

Bond Law Review, 1991
extract] It is well understood that the law which relates to the set-off of mutual dealings in bankruptcy, which has a long history, exists to prevent the injustice of a man who has had mutual dealings with a bankrupt from having to pay in full what he owes in respect of such dealings while only receiving a dividend on what the bankrupt owed him in ...
openaire   +3 more sources

How to ‘survive’ after graduating in science or engineering: Becoming an academic administrator

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This is the eighth article in the series ‘Survival Skills for Scientists’; previous papers were published in the Journal of Materials Education. Here I describe my views, based partly on personal experience, about pursuing an alternative career path within academia: becoming an administrator (e.g., Department Chair, Dean, Vice‐President ...
Federico Rosei
wiley   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Agilent Seahorse XF HS Mini‐Platform: A Comprehensive Guide for Real‐Time Analysis of Cellular Energy Metabolism

Food Safety and Health, EarlyView.
This comprehensive guide for the Agilent Seahorse XF HS Mini‐platform presents real‐time analysis of cellular energy metabolism across the mitochondrial stress test, glycolytic rate assay, and real‐time ATP rate assay, with applications in food safety and health and in metabolic disease.
Zhihao Liu, Fu Zhao, Qihao Li, Jihang Chen   +3 more
wiley   +1 more source