Results 31 to 40 of about 358,024 (354)

Oxidative stress and lipid peroxidation are upstream of amyloid pathology [PDF]

Neurobiology of Disease, 2015
Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the direct causative relationship between oxidative stress and amyloid pathology, and determining the underlying molecular mechanisms is crucial for the development of more effective therapeutics for the ...
Muriel Arimon, Shuko Takeda, Kathryn L. Post, Sarah Svirsky, Bradley T. Hyman, Oksana Berezovska   +5 more
openaire   +3 more sources

Antioxidant Effects of Grape Vine Cane Extracts from Different Chinese Grape Varieties on Edible Oils

Molecules, 2014
This study involved the determination of the peroxide value (POV) as a measure of the resistance of the oxidation of edible oil with grape vine cane additives to assess their antioxidation potential.
Zhuo Min, Zemei Guo, Kai Wang, Ang Zhang, Hua Li, Yulin Fang   +5 more
doaj   +1 more source

Anisidine value as a measurement of the latent damage of fats

Grasas y Aceites, 1991
Although the peroxide value is a common measurement of lipid oxidation, its use is limited to the initial stages of oxidation. Since peroxides are vulnerable to further decomposition, the complete oxidative history of the oil may not be revealed.
M. A. Grompone
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Oxidative damage of U937 human leukemic cells caused by hydroxyl radical results in singlet oxygen formation.

PLoS ONE, 2015
The exposure of human cells to oxidative stress leads to the oxidation of biomolecules such as lipids, proteins and nuclei acids. In this study, the oxidation of lipids, proteins and DNA was studied after the addition of hydrogen peroxide and Fenton ...
Marek Rác, Michal Křupka, Svatopluk Binder, Michaela Sedlářová, Zuzana Matušková, Milan Raška, Pavel Pospíšil   +6 more
doaj   +1 more source

Effect of Traditional Drying Methods on Proximate Composition, Fatty Acid Profile, and Oil Oxidation of Fish Species Consumed in the Far‐North of Cameroon

Global Challenges, 2020
The purpose of this study is to evaluate the effects of two traditional drying methods on proximate composition, lipid oxidation, and fatty acid composition of two freshwater fish species from Maga Lake in Cameroon.
Noël Tenyang, Roger Ponka, Benard Tiencheu, Fabrice Tonfak Djikeng, Hilaire Macaire Womeni   +4 more
doaj   +1 more source

FINO2 Initiates Ferroptosis Through GPX4 Inactivation and Iron Oxidation

Nature Chemical Biology, 2018
Ferroptosis is a non-apoptotic form of regulated cell death caused by the failure of the glutathione-dependent lipid-peroxide-scavenging network. FINO2 is an endoperoxide-containing 1,2-dioxolane that can initiate ferroptosis selectively in engineered ...
M. Gaschler, A. Andia, Hengrui Liu, J. Csuka, Brisa Hurlocker, Christopher A. Vaiana, Daniel W. Heindel, Dylan S Zuckerman, P. H. Bos, Eduard Reznik, L. Ye, Y. Tyurina, Annie J. Lin, M. Shchepinov, Amy Y Chan, Eveliz Peguero-Pereira, M. A. Fomich, Jacob D Daniels, A. Bekish, V. Shmanai, V. Kagan, L. Mahal, K. Woerpel, B. Stockwell   +23 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Induction of Peroxisomal β‐Oxidation as a Critical Mechanism for Ethanol‐Induced Hepatic Triglyceride Accumulation

FASEB BioAdvances
Excessive oxidation of ethanol has been well known to induce hepatic triglyceride accumulation, while the underlying pathogenic mechanisms are not fully demonstrated.
Yida Zhang, Wei Zhang, Yicong Li, Haoya Yao, Yaoqing Wang, Xiao Zhang, Jia Zeng   +6 more
doaj   +1 more source

Lipid Oxidation in Dispersive Systems with Monoacylglycerols

Czech Journal of Food Sciences, 2009
Model fat blends with a monoacylglycerol emulsifier with different acyl chain (C10, C12, C14, C16, C18, C18:1, C20, C22) were prepared and stored under oxygen atmosphere 8 weeks at temperature 20°C.
V. Spěváčková, I. Hrádková, M. Ebrtová, V. Filip, M. Tesařová   +4 more
doaj   +1 more source