Results 51 to 60 of about 93,194 (209)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Relationship between Person-Organization Fit and Organizational Identification among Staff Nurses [PDF]

open access: yesEgyptian Journal of Health Care
Background: Person-organization fit refers to conformity between individuals and organizations, which emphasizes the extent to which individuals and organizations share the same characteristics and/or meet each other's needs.
Rabab Mahmoud Hassan   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effect of Person-Organization Fit and Person-Job Fit on Performance with Organizational Citizenship Behavior as Mediation

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
This research aims to examine the impact of job fit and person-organization fit on performance, using organizational citizenship behavior as a mediating factor. This study approach is quantitative.
Nila Widi Purbaningrum   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

How Nurses’ Person-Organization Fit Influences Organizational Loyalty

open access: yesRisk Management and Healthcare Policy, 2023
Miaomiao Sun,1,2 Fahad Alam,3 Cunxiao Ma4 1School of Ethnology and Historiography, Ningxia University, Yinchuan, People’s Republic of China; 2The Party School of the CPC, Ningxia Hui Autonomous Region Party Committee, Ningxia Administration Institute ...
Sun M, Alam F, Ma C
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Relationship between Perceived Fit of Nurses and Organizational Citizenship Behavior in Shiraz Hospitals

open access: yesJournal of Research Development in Nursing and Midwifery, 2014
Background and Objective: This study aimed to investigate the relationship between perceived fit of nurses and organizational citizenship behavior. Material and Methods: The statistical population of this correlational study was all nurses of Shiraz ...
Abdozahra Naami   +3 more
doaj  

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