Results 51 to 60 of about 93,194 (209)
Tau acetylation at K331 has limited impact on tau pathology in vivo
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Relationship between Person-Organization Fit and Organizational Identification among Staff Nurses [PDF]
Background: Person-organization fit refers to conformity between individuals and organizations, which emphasizes the extent to which individuals and organizations share the same characteristics and/or meet each other's needs.
Rabab Mahmoud Hassan +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
This research aims to examine the impact of job fit and person-organization fit on performance, using organizational citizenship behavior as a mediating factor. This study approach is quantitative.
Nila Widi Purbaningrum +1 more
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
How Nurses’ Person-Organization Fit Influences Organizational Loyalty
Miaomiao Sun,1,2 Fahad Alam,3 Cunxiao Ma4 1School of Ethnology and Historiography, Ningxia University, Yinchuan, People’s Republic of China; 2The Party School of the CPC, Ningxia Hui Autonomous Region Party Committee, Ningxia Administration Institute ...
Sun M, Alam F, Ma C
doaj
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Background and Objective: This study aimed to investigate the relationship between perceived fit of nurses and organizational citizenship behavior. Material and Methods: The statistical population of this correlational study was all nurses of Shiraz ...
Abdozahra Naami +3 more
doaj

